The purpose of the present study was to examine the process of bone formation in the regenerating cranial appendages of roe deer (Capreolus capreolus) and fallow deer (Dama dama) during the early postcasting period. After the antlers are cast, osteoclastic and osteoblastic activities lead to a smoothing of the pedicle's separation surface, a strengthening of the pedicle bone, and a partial restoration of the distal pedicle portion that was lost along with the cast antler. Initially, bone formation occurs by intramembranous ossification, but early during the regeneration process cartilage is formed at the tips of the cranial appendages, and is subsequently replaced by bone in a process of endochodral ossification. Shortly after the antlers are cast, the cambium layer of the periosteum in the distal pedicle is markedly enlarged, which suggests that the periosteum serves as a cell source for the bone-forming tissue covering the exposed pedicle bone. The histological findings of our study are consistent with the view that the bony component of the regenerating cranial appendages of deer is largely derived from the pedicle periosteum. Based on findings in other bone systems, we speculate that stem cells that can undergo both osteogenic and chondrogenic differentiation are present in the pedicle periosteum. The early onset of chondrogenesis in the regeneration process is regarded as an adaptation to the necessity of producing a huge volume of bone within a short period. This parallels the situation in other cases of chondrogenesis in membrane bones. Anat Rec Part A 273A: 741-751, 2003.
The present study compared the concentrations of different elements (Ca, P, Mg, Sr, Ba, K, S, Zn, Mn) as well as Ca/P, Ca/Mg, Sr/Ca, and Ba/Ca ratios in hard antler and pedicle bone of yearling red deer stags (n = 11). Pedicles showed higher concentrations of calcium and phosphorus and a higher Ca/Mg ratio than antlers, while antlers exhibited higher concentrations of potassium, sulfur, and manganese as well as higher Ca/P, Sr/Ca, and Ba/Ca ratios. The findings indicate that antlers are less mineralized and show less maturation of their bone mineral than pedicles. Antlers also showed a higher intrasample variation of mineralization than pedicles, which can be related to the shorter life span of the (deciduous) antlers compared to the (permanent) pedicles. It is suggested that antler bone formation is stopped before the theoretically possible degree of mineralization and mineral maturation is reached, resulting in antler biomechanical properties (high bending strength and work to fracture) that are well suited for their role in intraspecific fighting. It is further suggested that the differences in Sr/Ca and Ba/Ca ratios of antlers and pedicles are related to the dietary shift from milk to vegetation in combination with an increasing intestinal discrimination against Sr and Ba with age, resulting in a less marked difference in these ratios than would be expected based on the dietary shift alone. The findings of our study underscore the suitability of antlers and pedicles as models of bone mineralization and the influence of different animal-related and/or external factors on this process.
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