Patients with chronic lymphocytic leukemia (CLL) harboring TP53 aberrations (TP53abs; chromosome 17p deletion and/or TP53 mutation) exhibit an unfavorable clinical outcome. Chromosome 8 abnormalities, namely losses of 8p (8p−) and gains of 8q (8q+) have been suggested to aggravate the outcome of patients with TP53abs. However, the reported series were small, thus hindering definitive conclusions. To gain insight into this issue, we assessed a series of 101 CLL patients harboring TP53 disruption. The frequency of 8p− and 8q+ was 14.7% and 17.8% respectively. Both were associated with a significantly (P < 0.05) higher incidence of a complex karyotype (CK, ≥3 abnormalities) detected by chromosome banding analysis (CBA) compared to cases with normal 8p (N-8p) and 8q (N-8q), respectively. In univariate analysis for 10-year overall survival (OS), 8p− (P = 0.002), 8q+ (P = 0.012) and CK (P = 0.009) were associated with shorter OS. However, in multivariate analysis only CK (HR = 2.47, P = 0.027) maintained independent significance, being associated with a dismal outcome regardless of chromosome 8 abnormalities. In conclusion, our results highlight the association of chromosome 8 abnormalities with CK amongst CLL patients with TP53abs, while also revealing that CK can further aggravate the prognosis of this aggressive subgroup.

Aneurysmal involvement of the celiac trunk in a patient with Behçet's disease is a rare pathology that appears amenable to stent-graft repair.

Education, videogames, and intelligent systems are all relevant topics for researchers. Determining means of improving academic performance using a range of techniques and tools is an important challenge. However, while there are currently websites and multimedia resources that help students to improve their knowledge on specific topics, these lack in not having intelligent agents that can evaluate students and recommend materials to suit the difficulty that a user is having in a given subject. In this sense, this paper aims at developing an intelligent system that allows interactive teaching in basic education using videogames. In particular, high school students’ skills in basic mathematical operations with fractions were used for testing experimentally the approach. An intelligent system was developed using computational techniques such as fuzzy logic and case-based reasoning to evaluate user performance and recommend additional study material according to the specific challenges from the given educational game. The use of the games was supported by ICT (information and communication technologies) tools on a web platform. Such a developed platform was tested by 206 high school students, who played 5400 games in total. The students showed an improvement of around 14% in the topics covered. The results indicate that the implementation jointly of videogames and intelligent systems allows users to improve their performance in the given topics.

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análisis sobre cómo, a nivel de los países desarrollados, la preocupación social por una delincuencia creciente y el mito de una Policía antidelito ha puesto a ésta en una situación de encrucijada ante su propio futuro. El texto reproduce el debate que abrió David H. Bayley hace tres años y que todavía no está cerrado. La idea es que el futuro de la Policía depende de la respuesta a una pregunta. La de si está dispuesta a asumir la prevención de la delincuencia como una actividad central, y las consecuencias del cambio organizativo y cultural que ello comporta. El artículo discute las posibilidades de una respuesta negativa o afirmativa y las consecuencias que tendría para la Policía y la sociedad del futuro.La Policía es una institución mítica. En general, el mundo cotidiano de la Policía es un mundo desconocido para los ciudadanos. Sin embargo, quizás no haya otra institución que se haya visto más retratada en la literatura, el cine y, en general, en los medios de comunicación. La imagen de la Policía en los medios de comunicación tiene una importancia central para reflejar la idea de 85/99 pp. 85-94 * Este artículo es una versión corregida y ampliada de una ponencia presentada en el Congreso Internacional sobre la Policía del Futuro: Mediación y proximidad, celebrado en L'Hospitalet de Llobregat (Barcelona) los días 13, 14 y 15 de noviembre de 1996. Fue debatida en la mesa redonda «Conflictos sociales y evolución de la demanda social a la policía».