Highlights d NLRP12 reduces interferon and cytokine responses to RNA viruses and 5 0 ppp-dsRNA d NLRP12 associates with TRIM25 to disrupt Lys63 ubiquitination and activation of RIG-I d Vesicular stomatitis virus (VSV) infection downregulates NLRP12 d Myeloid-specific Nlrp12-deficient mice have increased resistance to VSV
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