Background: Hippocampus segmentation on magnetic resonance imaging is of key importance for the diagnosis, treatment decision and investigation of neuropsychiatric disorders. Automatic segmentation is an active research field, with many recent models using deep learning. Most current state-of-the art hippocampus segmentation methods train their methods on healthy or Alzheimer's disease patients from public datasets. This raises the question whether these methods are capable of recognizing the hippocampus on a different domain, that of epilepsy patients with hippocampus resection. New Method: In this paper we present a state-of-the-art, open source, ready-to-use, deep learning based hippocampus segmentation method. It uses an extended 2D multi-orientation approach, with automatic preprocessing and orientation alignment. The methodology was developed and validated using HarP, a public Alzheimer's disease hippocampus segmentation dataset. Results and Comparisons: We test this methodology alongside other recent deep learning methods, in two domains: The HarP test set and an in-house epilepsy dataset, containing hippocampus resections, named HCUnicamp. We show that our method, while trained only in HarP, surpasses others from the literature in both the HarP test set and HCUnicamp in Dice. Additionally, Results from training and testing in HCUnicamp volumes are also reported separately, alongside comparisons between training and testing in epilepsy and Alzheimer's data and vice versa. Conclusion: Although current state-of-the-art methods, including our own, achieve upwards of 0.9 Dice in HarP, all tested methods, including our own, produced false positives in HCUnicamp resection regions, showing that there is still room for improvement for hippocampus segmentation methods when resection is involved.
The COVID-19 pandemic generated research interest in automated models to perform classification and segmentation from medical imaging of COVID-19 patients, However, applications in real-world scenarios are still needed. We describe the development and deployment of COVID-19 decision support and segmentation system. A partnership with a Brazilian radiologist consortium, gave us access to 1000s of labeled computed tomography (CT) and X-ray images from São Paulo Hospitals. The system used EfficientNet and EfficientDet networks, state-of-the-art convolutional neural networks for natural images classification and segmentation, in a real-time scalable scenario in communication with a Picture Archiving and Communication System (PACS). Additionally, the system could reject non-related images, using header analysis and classifiers. We achieved CT and X-ray classification accuracies of 0.94 and 0.98, respectively, and Dice coefficient for lung and covid findings segmentations of 0.98 and 0.73, respectively. The median response time was 7 s for X-ray and 4 min for CT.
In natural language processing (NLP), there is a need for more resources in Portuguese, since much of the data used in the state-of-the-art research is in other languages. In this paper, we pretrain a T5 model on the BrWac corpus, an extensive collection of web pages in Portuguese, and evaluate its performance against other Portuguese pretrained models and multilingual models on the sentence similarity and sentence entailment tasks. We show that our Portuguese pretrained models have significantly better performance over the original T5 models. Moreover, we showcase the positive impact of using a Portuguese vocabulary. Our code and models are available at https://github.com/unicamp-dl/PTT5.
Objectives: Automated computational segmentation of the lung and its lobes and findings in X-Ray based computed tomography (CT) images is a challenging problem with important applications, including medical research, surgical planning, and diagnostic decision support. With the increase in large imaging cohorts and the need for fast and robust evaluation of normal and abnormal lungs and their lobes, several authors have proposed automated methods for lung assessment on CT images. In this paper we intend to provide a comprehensive summarization of these methods.
Methods: We used a systematic approach to perform an extensive review of automated lung segmentation methods. We chose Scopus, PubMed, and Scopus to conduct our review and included methods that perform segmentation of the lung parenchyma, lobes or internal disease related findings. The review was not limited by date, but rather by only including methods providing quantitative evaluation.
Results: We organized and classified all 234 included articles into various categories according to methodological similarities among them. We provide summarizations of quantitative evaluations, public datasets, evaluation metrics, and overall statistics indicating recent research directions of the field.
Conclusions: We noted the rise of data-driven models in the last decade, especially due to the deep learning trend, increasing the demand for high-quality data annotation. This has instigated an increase of semi-supervised and uncertainty guided works that try to be less dependent on human annotation. In addition, the question of how to evaluate the robustness of data-driven methods remains open, given that evaluations derived from specific datasets are not general.
Airway segmentation in computed tomography images can be used to analyze pulmonary diseases, however manual segmentation is labor intensive and relies on expert knowledge. This manuscript details our contribution to MICCAI's 2022 Airway Tree Modelling challenge, a competition of fully automated methods for airway segmentation. We employed a previously developed deep learning architecture based on a modified EfficientDet (MEDSeg), training from scratch for binary segmentation of the airway using the provided annotations. Our method achived 90.72 Dice in internal validation, 95.52 Dice on external validation and 93.49 Dice on the final test phase, while not being specifically designed or tuned for airway segmentation. Open source code and a pip package for predictions with our model and trained weights are in https://github.com/MICLab-Unicamp/medseg.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.