Vaginal Penetration Disorders (VPD) consist a major sexual disorder that has a significant impression on young ladies and couple's relationships and also consist of a predisposing factor for anxiety disorders. All existing treatments of vaginismus are still a big challenge and often without success. Before performing PRP patients were referred to the gynaecologist, urologist or psychologist. Almost in every case after several attempts to be treated, they were disappointed with the results. Often, they have admitted to accept their problem and keep suffering because no physician could offer any effective help with significant results. We are reporting in this article a serie of ten cases where the Platelet Rich Plasma (PRP) treatment was tried based on their voluntary participation due to particular and relative sexual problems. Based on the results that are exposed here, we can say that PRP clearly has a positive effect not only on rejuvenation of the female genital structurebut also on improving VPD symptoms. It reduces pain, reduces mucosal dryness and chronic fissuration. The duration of the effect on the vaginal structure as well as clinical improvements requires more case studying and research. These patients will be evaluated for the coming 2 years to acquire more data to be analyzed in order to complete our observational study. It is nothing but the beginning of a new era in the sexual dysfunction therapy.
Objectives: This was a clinical audit, conduct to know the rational practice of anti-d prophylaxis in two early pregnancy complications. Methods: Information was gathered from 37 patients with early trimester miscarriages and 35 patients with ectopic pregnancies who admitted to Professorial gynecology ward, Teaching hospital, Peradeniya over single calendar year period. Data gathered from retrospectively from bed head tickets and recorded/ analysed with SPSS V21. Results: Among patients who had early trimester miscarriage mean age was 28.4(±6.4) years, mean period of gestations on admission was 123.9(±26.7) days. 21.6% were presented with per vaginal bleeding, 24.3% presented with abdominal pain and 37.8% were presented with both pain and the bleeding. 16.2% presented with the sonographic evidence of the missed miscarriage without any symptoms. Solely medical management done for 24.3%, solely surgical interventions done in 40.5% and in 35.1% of the occasion combination was used. Among the sample 81.1% were rhesus positive, 2.7% rhesus negative and 16.2% of the occasion rhesus status were not documented. Anti-D prophylaxis coverage was 100% in those who have undergone surgical management. Mean age of the patients with ectopic pregnancies were 30.4(±4.9) years, mean period of gestation was 51(±10.9, n=27) days. Surgical management was done in 94.3% of the occasion. Among them 2 were Rh negative and anti-D prophylaxis coverage was 100%. Conclusions: Early trimester miscarriages and ectopic pregnancies are presented with various presentations and managed medical, surgical or both methods. Among the population rhesus negative mothers were less and in some case rhesus status was not documented. It is essential to cover such rhesus negative mothers to minimise the future pregnancy related complications. Proper investigation, documentation and timely intervention will improve the quality of care. EP24.11Retrospective study on first trimester miscarriages in Teaching Hospital Peradeniya, Sri Lanka J.P. Jayasinghe 1 , C. Objectives: Teaching Hospital Peradeniya is one of the busy tertiary care hospital in Sri Lanka. The idea behind the study is to identify the pattern of miscarriage management in THP (Teaching Hospital Peradeniya) and use knowledge in future to optimise the care relate to miscarriages. Methods: Patients with history of bleeding and confirmed pregnancy were include into the study during one month period. Mothers with POA < 12 POA included into the study and 50 patients with inclsion criteria were identify. Six belongs to POA >12 weeks and didn't include into the study. Results: 22 patients had conservative management as the method of treatment for miscarriage management. But this includes mothers with Threaten miscarriage and those who come with complete miscarriages.12 patients end up as medical management with one dose of Misoprostol and 2 Patients following 2 doses of misoprostol. 3 patients end up as surgical management as their 1st line management choice.11 patients had failed medical management and h...
Breast cancer is the most common cancer in women and is a major public health problem. It is divided into several subtypes, including triple negatives. The general objective of our study is to establish the profi le and the management of patients with triple negative breast cancer over a period of 2 years, operated in our department. During our study period, triple-negative breast cancers accounted for 10% of our population. The most aff ected age group ranges from 50 to 60. The majority of patients in our sample are pauciparous. In the group of patients who received hormone therapy, it was mainly HRT for 4 to 6 years. 96.77% of patients consulted a health worker within 3 months of the discovery of the signs. Adenopathies are frequently present at the time of diagnosis. 93.54% of the cases have an invasive ductal carcinoma. Triple negative cancers are essentially poorly diff erentiated. Triplenegative cancer has a high rate of cell renewal. In our study, neoadjuvant chemotherapy is mostly indicated for triple-negative breast cancers ≥ 30 mm at diagnosis and a delayed lumpectomy is then performed in 23.52% of the patients. For tumors of < 30 mm size, a lumpectomy is performed immediately in 76.47% of the patients, followed by adjuvant chemotherapy. Mastectomy was performed in 45.16% of patients; it was mainly indicated in front of a large tumor size associated with a small breast volume, then multifocal breast tumors. Breast reconstruction was performed in 21.42%. Radiation therapy is indicated in the majority of patients, postoperatively. In our population, 11 patients were proposed to have an oncogenetic survey; it was mainly indicated based on the Manchester criteria in front of a young age and a family history of cancer. There are two BRCA 1 mutations, one BRCA 2 mutation, and one case of absence of mutation. The therapeutic intake in case of a mutation is directed towards a prophylactic bilateral mastectomy and adnexectomy, proposed at the age of 40. Two patients had presented triple negative recurrences of their already treated breast cancer; fi rst case PDL1 positive PD-L1 ≥ 1% treated with immunotherapy combined with chemotherapy (atezolizumab/abraxane) while the second and second PDL1 negative treated with chemotherapy alone. Despite their low frequency, triple negative breast cancers represent a subgroup marked by pejorative characteristics, a reserved prognosis, with limited treatment options.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.