A 34-year-old woman developed a chyle leak after removal and replacement of her breast prostheses. This is the first such case reported in the literature. We discuss the diagnosis and management of this rare and interesting case.
We model push factors that determine the domestic migration decisions for couples, with emphasis on dual-earner different-sex couples. Unlike many prior studies that concentrate on labour market determinants of migration, we place the subjective well-being (SWB) reported by each partner at centre stage. We test whether migration determinants differ depending on whether the female is the main breadwinner in a dual-earner couple. We also test if determinants differ when either the female or the male is the sole earner within a couple. The evidence shows that a couple is more likely to migrate if she reports low SWB in the year prior to migration, with the strength of this effect varying depending on the earnings status of each partner prior to migration. Male SWB does not have the same impact on the migration choice although we find some evidence that pre-migration male wages impact the migration decision.
The cancer genomics field has embraced the advent of precision oncology, and vast volumes of data have been mined for biomarkers of drug actionability. While some cancers have detailed panels of actionable genomic biomarkers, such as lung cancer, breast cancer has been less well-placed to apply standard sequencing panels given its large number of cancer driver genes mutated at a relatively low frequency. Furthermore, mutation signatures have potential to play an important role in the targeting of homologous recommendation deficiency-driven tumours to PARP inhibitor therapy. To investigate whether whole genome sequencing could benefit breast cancer patients we initiated the Q-IMPROvE (Queensland-IMplementation of PRecision Oncology in brEast cancer) pilot study. We report the analysis of matched tumour and normal genomes of 28 high-risk breast cancer patients, and demonstrate that there are detectable, actionable events that would otherwise have not been identified.
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