Neurological complications are frequent occurrences in children and adolescents with sickle cell disease (SCD). This research has investigated the prevalence of neurovascular and neurocognitive impairments in 17 patients with SCD from Northern Brazil, with aged 6-16 years. Transcranial Doppler Ultrasound (TDU) examinations were performed on patients employing the STOP protocol as a risk score to predict stroke. Neuropsychological assessments were also performed: the Wechsler Intelligence Scale for Children - 4th Edition (WISC-IV). Fisher's Exact Test was used for statistical analyses (p ≤0.05) of the collected dataset. Frequent headaches were a common clinical finding, occurring in over 75% of the children. There were no alterations in cerebral hemodynamics on TDU for over 70% of the patients. In general, patients had below-average scores on most cognitive domains. There was a tendency for correlation between transcranial Doppler results and the WISC-IV indices of total Intelligence Quotient (p = 0.069) and Processing Speed Index (p = 0.082). Conclusion: Most SCD patients showed impairments on cognitive tests, but there was no statistically significant correlation between the presence of neurovascular damage and worse performance on the tests.
Junior, meu orientador, agradeço pela oportunidade e por todo o crescimento profissional que tive durante o período do doutorado em que participei do seu grupo de pesquisa. À Prof.ª Dr.ª Ana Lilia Alzate Marin, por todo apoio que recebi no início do doutorado. Ao Dr. João Guerreiro da Universidade Federal do Pará (UFPA) e Dr.ª Heloisa Bettiol (HC-USP), pela parceria no desenvolvimento desse projeto de doutorado. Muito obrigada. Ao meu pai Ribamar pelo amor incondicional, carinho, apoio e compreensão. Sempre me apoiando e incentivando a ir o mais longe que puder na busca do conhecimento. À minha mãe Eliana (in memoriam) que mesmo partindo cedo, me deu a vida e motivação para ser uma pessoa melhor. Aos meus irmãos Marcos e Márcia, por serem um dos pilares que me fortalecem todos os dias. Sou muito abençoada e agradecida por tê-los em minha vida. À minha grande e querida família, por todo carinho de sempre. Em especial à minha amada tia Lúcia e minha amada vó Dolores, que deram o melhor si para que eu tivesse um caráter ilibado e uma educação exemplar. As amo como uma filha ama sua mãe.
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