Acute lymphoblastic leukemia (ALL) is the most frequent malign hematologic disease in children. We studied the hematologic toxicity caused by the cytostatic treatment which was administered to the children diagnosed with ALL, according to the ALL-IC-BFM 2002/2009 protocol. The study included a number of 15 children with ALL who were treated from 2008 to 2018 within the Oncopediatrics Department of the 2nd Pediatric Clinic of the Emergency County Hospital in Craiova. We decided upon the level of toxicity in blood values, taking into account the severity level (G), according to the Common Terminology Criteria for Adverse Events 2010 guideline and we calculated the mean value of the hemoglobin, leukocytes, neutrophils, and thrombocytes in the children with ALL, for every phase of the cytostatic treatment. The most severe toxicity (grade 4 of severity) was registered in neutrophils (7/15 patients), during the induction and re-induction periods; 4 of these patients had severe infections.
Ageing is defined as a slow, irreversible process of cellular changes, that are due to a lack of balance between degradation and repair, a continuous interaction between physiological and pathological processes. Physiological aspects in elderly people are often confused with disease. Given these general considerations, we would make observations about the dynamics of cortisol secretion in healthy elderly subjects and patients with a diagnosed cardiovascular disease, more precisely hypertension. The study was conducted during 2003–2010, on a number of 135 patients older than 65 years of age, who were divided into two groups: one group counting 66 patients and consisting of healthy elderly controls (without systemic disease, renal, endocrine, or cardiovascular known issues) and group 2 who consists of 69 elderly patients who associate known hypertensive and other cardiovascular issues.
Cystic fibrosis (CF) or mucoviscidosis, although considered a rare disease, is the most common genetic disease with autosomal recessive transmission of the Caucasian race. The study included 13 children aged between 0 and 18 years diagnosed with CF between 01.01.2000 and 31.12.2018, being recorded, monitored and treated in the Regional Center for CF Craiova from the Pediatrics II Clinic, County Emergency Clinical Hospital Craiova, Romania. For each patient we evaluated the following parameters: the year of CF diagnosis, the age at diagnosis, sex and environment of origin, clinical manifestations at onset, evolution of treatment cases by 2018. Of the 13 children with CF in study, most of them (11) are male. The most common clinical manifestations were the respiratory ones. Genetic tests were performed on all children, highlighting that 6 out of 13 children were homozygous �F508 and 2 children had mutations not genetically identified, requiring sequencing.
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