The objective of this research was to investigate the effect of gamma irradiation on mechanical and thermal properties of fish gelatin films prepared from scales of Lates calcarifer. The films were irradiated by gamma rays at varied doses (0-50 kGy). The mechanical and thermal properties of irradiated gelatin films were measured by using colorimeter, Universal Testing Machine, Differential Scanning Calorimetry (DSC), and Fourier Transform Infrared (FTIR) spectrophotometer. The results showed that increasing of irradiation dose up to 50 kGy, the color of irradiated film did not change significantly (p < 0.05). The tensile strength of irradiated film was increased with no differences among dose variation but there was no change on elongation at break value (p < 0.05). The DSC spectra of irradiated gelatin films showed that irradiation did not affect melting temperature (Tm). In contrast, the glass transition temperature (Tg) of irradiated film has slight tendency to increase with increasing of radiation doses. In general, the FTIR spectra confirmed that gamma irradiation up to 50 kGy affected the mechanical properties of gelatin films.
Fast swelling hydrogels were synthesized from the mixture of acrylamide (AAM)-acrylic acid (AA)-starch (15:5:1 w/v) solution by radiation crosslinking with varying irradiation doses (7.5-12.5 (7,(5)(6)(7)(8)(9)(10)(11)(12)5
ABSTRAK
Hidrogel dengan kemampuan swelling yang relatif cepat disintesis dari campuran larutan akrilamida (AAM)-asam akrilat (AA)-pati (15:5:1) menggunakan iradiasi gamma pada beragam dosis iradiasi
kGy). Kopolimer dikarakterisasi menggunakan Fourier Transform infra red (FTIR) dan Differential scanning calorimetry (DSC
Penelitian ini bertujuan memanfaatkan hidrogel sebagai matriks imobilisasi obat dengan teknik iradiasi gamma untuk mengontrol laju pelepasan obat terkendali. Imobilisasi propanolol HCl dalam hidrogel poli(vinil alkohol) (PVA)-g-natrium alginat (NaAlg) telah dilakukan. Larutan PVA/NaAlg (5/0,5, %berat) yang mengandung propanolol HCl (8 mg sampai dengan 16 mg), dibeku-lelehkan (3 siklus) dan diradiasi dengan variasi dosis (10 kGy sampai dengan 30 kGy). Hidrogel dikarakterisasi dengan spectrophotometer Fourier Transform-Infra Red (FT-IR) dan Scanning Electron Microscope (SEM). Fraksi gel dan daya serap air ditentukan secara gravimetri. Uji pelepasan propanolol HCl dari hidrogel dilakukan dalam larutan encer fosfat (pH 6,8) pada suhu 37 °C diukur dengan spectrofotomer Ultraviolet Visible (UV-Vis). Hasil evaluasi menunjukkan peningkatan dosis iradiasi dari 10 kGy hingga 30 kGy, peningkatan fraksi gel hidrogel, dan kemampuan menyerap air hidrogel relatif turun. Pelepasan kumulatif obat dari matriks hidrogel dengan meningkatnya dosis iradiasi hingga 30 kGy relatif turun. Pengamatan menggunakan SEM, menunjukkan hidrogel PVA-NaAlg mempunyai struktur pori yang tidak teratur. Hidrogel PVA-g-NaAlg selayaknya dapat digunakan sebagai matriks pelepasan obat.
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