Imobilisasi Propanolol HCl Pada Hidrogel Poli(Vinil Alkohol) - Natrium Alginat Dengan Teknik Radiasi

Erizal, Erizal; Pratiwi, Erlina Widianti; Perkasa, Dian Pribadi; Noviyantih, Noviyantih; Abbas, Bahtiar Saleh; Sudirman, Sudirman

doi:10.24817/jkk.v40i1.2755

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…At 10 kGy irradiation dose, the gel fraction decreased from approximately 68 % to approximately 48 %, while at 20 kGy irradiation dose the gel fraction decreased from approximately 80 % to approximately 48 % Due to the formation of peroxide compounds, the gel fraction of PVA-gelatin hydrogels did not reach 100 % as a by-product of the reaction of monomers/polymers with water-soluble oxygen and unreacted monomers/polymers. [19,20] and the possibility of gelatin not being completely crosslinked with increasing gelatin concentration [21,22].…”

Section: Effect Of Gelatin Concentration and Irradiation Dose On Gel ...mentioning

confidence: 99%

Synthesis of Polyvinyl Alcohol (PVA)-Gelatin Hydrogel from White Snapper (Lates calcarifer, Bloch) with Gamma Irradiation and Its Characterizations

Hariyanti,

Erizal,

Apriyani

et al. 2023

Atom Indo.

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The application of nuclear technology in the health sector is increasing. One example is the use of irradiation in production of wound dressings. Research activities have been conducted to study whether polyvinyl alcohol (PVA)-gelatin-based hydrogel from white snapper scales can be processed using gamma irradiation into wound dressings. A series of PVA (10 %) solutions containing gelatin in various concentrations (0-4 %) were treated with three freeze-thaw cycles and then irradiated at doses of 10 and 20 kGy. They were subsequently characterized using Fourier transform infrared (FTIR) spectroscopy and scanning electron microscope (SEM). Gel fraction, water absorption, and percentage of hydrogel water evaporation rate were tested gravimetrically, while the elongation at break and the tensile strength of the hydrogels were tested with a universal testing meter. The evaluation showed that the hydrogel gel fraction decreased with increasing gelatin concentration from 0 % to 4 % for both irradiation doses (10 and 20 kGy). The rising gelatin concentration demonstrated that increasing gamma radiation dose improved the hydrogel's water absorption, evaporation rate, tensile strength, and elongation at break. PVA-gelatin hydrogel with irregular pore structure was observed from SEM test results. The FTIR measurement results confirmed the formation of crosslinks in the hydrogel matrix. The PVA-gelatin hydrogel produced through gamma irradiation could be used for wound dressings.

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Section: Effect Of Gelatin Concentration and Irradiation Dose On Gel ...mentioning

confidence: 99%

Synthesis of Polyvinyl Alcohol (PVA)-Gelatin Hydrogel from White Snapper (Lates calcarifer, Bloch) with Gamma Irradiation and Its Characterizations

Hariyanti,

Erizal,

Apriyani

et al. 2023

Atom Indo.

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“…Hidrogel adalah salah satu jenis makromolekul polimer hidrofilik yang berbentuk jaringan berikatan silang, mempunyai kemampuan mengembang dalam air (swelling), dan memiliki daya difusi air yang tinggi. Oleh karena sifat fisik yang khas tersebut, pada awalnya hidrogel disintesis untuk digunakan sebagai kontak lensa dan imobilisasi enzim dan sel [1,2,3,4,5,6]. Bila reaksi ikatan silang lebih dominan daripada reaksi degradasi, maka polimer tersebut bersifat ikatan silang (crosslinking), sebaliknya bila degradasi lebih dominan maka polimer tersebut bersifat degradasi [7].…”

Section: Pendahuluanunclassified

Development Of Polyethylene Oxide Film Hydrogels With The Addition Of Banana Sap For Wound Dressing Applications

Titani

Haryanto

2020

techno

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Hydrogels having been developed so far are those with polymer bases without any additives. For the acceleration of wound healing, it can be developed hydrogels with the addition of banana sap (Musa Paradisiaca) as a drug that is expected to accelerate the wound healing process. The preparation of Banana PEO-PEGDMA-Hydrogel Banana was made using a new method of dissolving banana juice with PEO-PEGDMA before crosslinking. The formulations of banana sap concentration used ranged from 0% to 15% (volume) and they were irradiated with gamma rays. The characteristics measured include gel fraction, swelling ratio, velocity of water vapor transmission and mechanical properties. The chemical and morphological structures were analyzed using the Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscope (SEM). The acceleration of wound healing speed was analyzed by invivo test. The results showed that the value of gel fraction, swelling ratio and velocity of water transmission of PEO-PEGDMA-Banana Gum hydrogel increased at a concentration of 0-15%. Hydrogel tensile strength decreased with the addition of banana sap and conversely the percentage of elongation of hydrogel increased with it. PEO-PEGDMA hydrogel film with the addition of banana sap has been proven to accelerate the wound healing through the Invivo Test. This shows that hydrogels can be developed from PEO-PEGDMA- Banana Sap which can be used as wound dressing.

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“…7 Some of the widely used resorbable membrane materials are polylactic acid, polyglycolic acid, poly lactic-coglycolic acid copolymer, and collagen membrane. 8 9 10…”

Section: Introductionmentioning

confidence: 99%

Determination of the Sterilization Dose of Gamma-Ray Irradiation for Polyvinyl Alcohol-Collagen-Chitosan Composite Membrane as a Material for Periodontal Regenerative Surgery

et al. 2023

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Objective Membrane sterility is very necessary considering its function as an implant material. Therefore, this research aims to determine the dose of gamma-ray irradiation for the sterilization of polyvinyl alcohol (PVA)–collagen–chitosan composite membranes used as regenerative surgery materials. Materials and Methods A total of 100 pieces of the composite membranes were prepared in a size of 2.0 × 1.5 cm by mixing 7.5% PVA, 3% collagen, and 2% chitosan using the film casting method in three batches. Furthermore, the bioburden test was performed to determine the initial microbial count in the sample by following ISO 11737-1. The results were used to ascertain the dose of gamma-ray irradiation on the sample according to ISO 11137-2. The dose verification test was then performed at the sterility assurance level 10−6. Results The average result of the bioburden test from three batches was 6.6 colony forming unit; hence, the verification dose was 4.8 kGy. In the verification dose test, since there was only one contaminated sample, the sterility dose test was continued. Conclusion The sterile gamma-ray irradiation dose for PVA–collagen–chitosan composite membrane was 17.1 kGy.

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Imobilisasi Propanolol HCl Pada Hidrogel Poli(Vinil Alkohol) - Natrium Alginat Dengan Teknik Radiasi

Cited by 4 publications

References 8 publications

Synthesis of Polyvinyl Alcohol (PVA)-Gelatin Hydrogel from White Snapper (Lates calcarifer, Bloch) with Gamma Irradiation and Its Characterizations

Synthesis of Polyvinyl Alcohol (PVA)-Gelatin Hydrogel from White Snapper (Lates calcarifer, Bloch) with Gamma Irradiation and Its Characterizations

Development Of Polyethylene Oxide Film Hydrogels With The Addition Of Banana Sap For Wound Dressing Applications

Determination of the Sterilization Dose of Gamma-Ray Irradiation for Polyvinyl Alcohol-Collagen-Chitosan Composite Membrane as a Material for Periodontal Regenerative Surgery

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