Kata kunci:primary dysmenorrhea fast food teen ABSTRAK
Angiotensin Converting Enzyme (ACE) is a zinc metallopeptidase that has a significant role in blood pressure regulation and the pathophysiology of hypertension. ACE has two protein domains, the N-domain and the C-domain, which each has a single active site that functions independently of each other. There is insertion/deletion by 288 bp Alu elements in the intron 16 of ACE gene. The Alu elements potentially alter splicing process. The effect of the insertion of Alu elements in the splicing pattern of the ACE gene has not been reported. Here, we report on the results of splicing pattern analysis of the ACE gene due to the insertion of Alu elements. Using an in-silico approach, we found the presence of Alu elements insertion in intron 16 of ACE caused alternative splicing and experienced exonization. Further analysis showed that the exonization lead to a premature termination codon (PTC), which is raised protein shortening and lost one of its two protein domains. The loss of one protein domain may affect the catalytic activity of ACE. These findings suggest that the Alu elements I/D polymorphism is related to the differences in the catalytic activity of ACE that may influence blood pressure regulation and hypertension.
The incidence of dysmenorrhea is very large world wide. Over 50% of women in every country experience menstrual pain. In America 60%, and in Sweden 72%, while in Indonesia the incidence of dysmenorrhea 64.25%. Primary dysmenorrhea is caused by a diet suchas fast food diet. This study aim'ed to determine the relationship of fast food with the incidence of Dysmenorrhea in SMPN 1 Ponorogo. The design used this study was correlation with the population of 170 respondents. Sampling technique used was purposive sampling with the sample of 63 respondents. Data collection instrument for dsyminore investigation Menstrual Symptom Questionnaire (MSQ), and for fast food frequencies investigation used the Food Frequency Questionnaire (FFQ). Chi-Square statistical test with significance level <0,05. From the result of the research to 63 respondents there were 35 respondents (55.6%) often consume fast food with genesis dysmenorrhea of 27 respondents (42.9%) and 8 respondents (12.7%) were not dysmenorrhea, while 28 respondents (44.4%) rarely consumed fast food get 14 respondents (22.2%) are dysmenorrhea and 14 respondents (22.2%) are not dysmenorrhea. Chi-square test results obtain p value 0.025 (p <0.05).Conclusion there is a fast food eating relationship with the incidence of dysmenorrhea, with the Contingency Coefficient closeness of 0.272. Abstrak Angka kejadian dismenore didunia sangat besar. Lebih 50% perempuan di setiap negara mengalami nyeri menstruasi, di Amerika 60%, dan di Swedia 72%, sementara di Indonesia sebesar 64.25%. Dismenore primer disebabkan oleh diet atau pola makan makanan cepat saji. Penelitian ini bertujuan untuk mengetahui hubungan mengonsumsi makanan cepat saji (fast food) dengan kejadian dismenore di SMPN 1 Ponorogo. Desain penelitian ini adalah korelasi dengan jumlah populasi 170 orang. Tehnik sampling menggunakan purposive sampling dengan sampel 63 responden. Pengumpulan data menggunakan kuesioner MSQ (Menstrual Symtom Questionnaire dan untuk frekuensi makanan cepat saji menggunakan FFQ (Food Frequency Questionnaire). Uji Statistic Chisquare dengan taraf signifikansi <0,05. Dari hasil penelitian terhadap 63 responden terdapat 35 responden (55.6%) sering menggonsumsi fast food dengan kejadian dismenore 27 responden (42.9%) dan 8 responden (12.7%) tidak dismenore, sedangkan 28 responden (44.4%) jarang menggonsumsi fast food didapatkan 14 responden (22.2%) dismenore dan 14 responden (22.2%) tidak dismenore. Hasil uji chi-Square diperoleh p value 0.025 (p < 0.05), yang berarti ada hubungan mengonsumsi makanan cepat saji.
AbstrakPendahuluan: Vulvae merupakan area sensitif dan mudah terinfeksi saat menstruasi karena kuman dapat dengan mudah masuk dan menyebabkan penyakit pada saluran reproduksi. Salah satu gangguan remaja saat menstruasi adalah gatal-gatal di sekitar vulva yang disebut pruritus vulvae. Tujuan Penelitian: untuk menganalisis hubungan perilaku personal hygiene saat menstruasi dengan kejadian pruritus vulva pada remaja putri. Metode Penelitian: Jenis penelitian ini menggunakan kuantitatif analitik dengan desain cross sectional. Populasi seluruh siswa kelas VII MTS Negeri 1 Madiun adalah 141 siswa dan sampel sebanyak 42 responden, dengan menggunakan teknik simple random sampling. Instrumen dalam penelitian ini menggunakan kuesioner, pengolahan data editing, coding, scoring dan tabulating, dalam analisis menggunakan uji statistik Chi-Square dengan α 0,05. Hasil Penelitian : Hasil dalam penelitian ini adalah sebagian besar responden memiliki perilaku personal hygiene menstruasi yang negatif sebanyak 22 remaja (52,4%) dan setengahnya sebanyak 20 responden (47,6%) berperilaku positif, serta sebagian besar 22 responden (52,4%) mengalami kejadian pruritus vulvae, dan hampir setengahnya 20 responden (47,6%) tidak mengalami kejadian pruritus vulvae. Kesimpulan : Didapatkan p value (0,000) α (0,05) yang berarti H1 diterima dan H0 ditolak yang artinya ada hubungan antara perilaku personal hygine dengan kejadian pruritus vulvae di MTS Negeri 1 Madiun. Saran : Responden yang terjadi pruritus vulvae dapat mencari informasi tentang perilaku personal hygine yang benar sehingga kejadian pruritus vulvae dapat dihindari. Untuk menurunkan kejadian pruritus vulvae, responden dihimbau untuk memperhatikan kebersihan vulvae, menerapkan perilaku personal hygine yang positif terutama ketika terjadi menstruasi agar terhindar dari pruritus vulvae. Kata kunci: Perilaku Personal Hygiene, Pruritus Vulvae, Remaja Putri
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