Experiment teaching of biochemistry and molecular biology is indispensable to undergraduate medical education. In the context of COVID-19 epidemic, how to combine a virtual simulation platform with biochemistry laboratory experiments organically is a pressing problem that must be faced and solved. Based on the theories of "student-centered" and "cone of experience", department of biochemistry of Qiqihar Medical University took teaching mode of virtuality and reality combination as the research direction of exploration. Students learned the virtual simulation experiments, and improved their professional practical skills in traditional laboratory. Different from the traditional experiment teaching, the instructional design of virtuality and reality combination not only focused on improving students' acquisition of knowledge, but also paid attention to students' development of abilities and emotions. It could effectively improve the experiment teaching effect and strengthen the cultivation of innovative talents, which will greatly promote the reform of biochemistry experiment teaching in medical colleges and universities.
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