Fast and selective: The aerobic oxidative ring opening of oxazolidine 1 in the presence of a catalytic amount of the chiral N‐hydroxyphthalimide analogue 2 was accompanied by efficient kinetic resolution of the oxazolidine. Thus, 50.5 % conversion was attained within 2 h, and the remaining 1 had an ee value of 89 %. The corresponding stereoselectivity factor, s=krel(fast/slow), is very high at around 40.
Schnell und selektiv: Die aerobe oxidative Ringöffnung des Oxazolidins 1 in Gegenwart katalytischer Mengen des chiralen N‐Hydroxyphthalimid‐Analogons 2 resultierte in einer effizienten kinetischen Racematspaltung. Binnen 2 h war ein Umsatz von 50.5 % erreicht, und das verbliebene Oxazolidin 1 hatte ee‐Werte von 89 %, was einem hohen Stereoselektivitätsfaktor s=krel(schnell/langsam) um 40 entspricht.
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