Inflammation is a normal process designed to protect oneself and promote healing of body tissues. The mechanism of action of flavonoids as antiinflammatory is through the inhibition of arachidonic acid and the secretion of lysosomal enzymes. The ethanol extract of Mangifera indica L. leaves (EEML) contains flavonoids and is widely used as a medicine empirically. This study was conducted to evaluate the antiinflammatory effect of EEML in vitro and in vivo. In vitro study of the antiinflammatory activity of EEML based on its effect on the stability of blood membranes using UV-Vis spectrophotometry method. While the in vivo activity was tested using the carrageenan induction method on white rats of the Wistar strain. In vitro activity was expressed as EC50 and in vivo activity was expressed as % edema reduction. The results showed that ethanol extract was able to increase membrane stability with an EC50 value of 8.56 ?g/ml better than positive control aspirin with EC50 21.57 ?g/ml. In vivo test results showed that the administration of EEML doses of 200 mg/kg.bw, 400 mg/kg.bw, and 800 mg/kg.bw was not significantly different from the positive control in reducing edema. EEML has shown antiinflammatory effects in vitro and in vivo, so it has the potential to be developed as an antiinflammatory agent.
Coriander (Coriandrum sativum) is a popular spice plant in Indonesia. Some active compounds contained in coriander seeds can be used as natural analgesics. This study aims to identify the functional groups contained in coriander seed extract. The solvent used to make coriander seed extract is ethanol and n-hexane, while the extraction method uses sohxlet. The extract obtained was then identified by its functional group using an Infrared spectrophotometer. The results of the identification of functional groups in the ethanol extract of coriander seeds showed some uptake that appeared at a wavelength of 3371.29 cm-1; 2923.59 cm-1; 2853.95 cm-1; 1583.22 cm-1; 1400.71 cm-1, and 1074.80 cm-1. The results of the identification of functional groups in the n-Hexane extract of coriander seeds showed some uptake that appeared at wavelengths of 2923.32 cm-1; 2853.41 cm-1; 1745.36 cm-1; 1461.9 cm-1; 1376.54 cm-1, 1161.67 cm-1, and 919.32 cm-1.
Coriander (Coriandrum sativum) is one of the medicinal plants which is known to contain secondary metabolites such as flavonoids, tannins, terpenoids, saponins, steroids, and alkaloids. Alkaloids have therapeutic effects as antimalarials and cancer. Research in determining the alkaloids in coriander was carried out by separating the alkaloids from other substances using the soxhlet method extraction with two solvents ethanol and n-hexane. The total alkaloid content is determined using a UV-VIS spectrophotometer at wavelength 351,5 nm. The reaction of alkaloids with Bromocresol green (BCG) is obtained to form a yellow product. The use of berberine standard was obtained the total alkaloid content of ethanol and n-hexane extract in coriander seed (Coriandrum sativum) were 0.524% and 0.583% respectively, and the ratio of total alkaloid content of ethanol extract was smaller than that of n-hexane extract.
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