Adverse long-term survival of intensive care and hospital patients was demonstrated. For hospital patients there was additional infection-related mortality risk, not evident for ICU patients after case mix control.
Hepatic portal venous gas (HPVG) results from mesenteric ischemia and a wide variety of other causes. The primary factors that favour the development of this pathologic entity are intestinal wall alterations, bowel distension, and sepsis. Findings of HPVG during an ultrasound or computed tomography (CT) scan should be carefully evaluated in the context of the clinical picture. In the absence of features of bowel ischemia, the prognosis of patients with HPVG is usually good.
Most ARISE participants did not meet the Sepsis-3 definition for septic shock at baseline. However, the majority fulfilled the new sepsis definition and mortality was higher than for participants not fulfilling the criteria. A quarter of participants meeting the new sepsis definition did not fulfill the qSOFA screening criteria, potentially limiting its utility as a screening tool for sepsis trials with patients with suspected infection in the ED. The implications of the new definitions for patients not eligible for recruitment into the ARISE trial are unknown.
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