Transformations of sulfane sulfur compounds (e. g. organic polysulfides (R−Sn−R, n>2) and elemental sulfur (S8)) play pivotal roles in the biochemical landscape of sulfur, and thus supports signaling activities of H2S. Although a number of previous reports illustrate amine mediated reactions of S8 and thiol (RSH) yielding R−Sn−R, this report illustrates that a tripodal [ZnII] complex [(Bn3Tren)ZnII−OH2](ClO4)2 (1) facilitates the reactions of sulfane sulfur and thiol (RSH), thereby offering an amine‐free biologically relevant complementary route. UV‐vis monitoring of the reactions and a set of control experiments underline the definitive role of [ZnII] coordination motif in the reactions of sulfane sulfur (e. g. S8 and R−Sn−R) with RSH. Detailed investigations (UV‐vis, NMR, ESI‐MS, intermediate trapping, and TEMPO radical interference experiments) disclose the key differences in the [ZnII] versus previously known amine mediated routes. Moreover, the persulfide (RSS−) trapping experiments using 1‐fluoro‐2,4‐dinitrobenzene (F‐DNB) reveal the intermediacy of RSS− species in the [ZnII] mediated reactions of sulfane sulfur and thiol, thereby demonstrating [ZnII] assisted persulfidation of thiol in the presence of sulfane sulfur species. Of broader impact, this study underscores the feasible influence of biologically relevant [ZnII] coordination motifs (e. g. carbonic anhydrase) on the sulfane sulfur chemistry in biology.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.