Objective: To document general baseline data on the patterns of childhood malignant tumors in a surgical pathology department. Design, Setting and Participants: This is a retrospective analysis of 35 cases of pediatric tumors in surgical pathology department of tertiary care hospital excluding neurosurgery, cardiothoracic and haemato-lymphoid malignancies. (Age group 0-12 years) encountered over a period of 5 years. Results: 35 children were diagnosed with malignant tumors. The commonest tumor was wilms tumor (9 out of 35 cases) followed by neuroblastoma (4 out of 35 cases). The common age of presentation was 1-5 years with male predominance. In the renal tumors only wilms tumors (9 cases) was seen, with classical triphasic tumors were more common. The mean age of presentation was 3 year with commonest age group of presentation (8 cases out of 9) in the age group 1-5 years. Three of them had showed unfavorable histology. In the adrenal gland, adrenal medullary tumors were more common than adrenal cortex with neuroblastoma (4 of 6 cases) as common individual tumor. Immunohistochemistry performed on 10 of 11 round cell tumors revealed five cases of lymphoma, three cases of Rhabdomyosarcoma (RMS) & two cases of Ewing sarcoma-primitive neuroectodermal tumor (EWS/PNET). Conclusion: Histological type is important for understanding etiology and progression of disease. The likelihood of a given type of tumor being present in a particular age or sex group or particular site may heighten the index of suspicion and ultimately influences etiology, biology, and natural history, relative incidence and distribution frequency, clinical presentation and manifestations, and response to therapy and outcome.

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