The aims of this study were (i) to determine the seminal fluid parameters, levels of serum reproductive hormones, testicular size and diameter of seminiferous tubules depending on multiple testicular biopsies from non-obstructive azoospermic (NOA) patients, and (ii) to assess the effect of smoking on concentrations of serum reproductive hormones. Thirty four NOA patients were involved in the present study. The selection of patients was based on an average of 2 pelleting seminal analysis, reproductive hormones profile and diagnostic testicular biopsy. A detailed questionnaire was used to obtain a thorough history from the patients. The results of this study showed that the mean age of NOA patients with Sertoli cell only syndrome (SCOS) was 33.875 years, and 47.05 % of NOA patients have had 2-4 years duration of infertility. Macroscopic examination of seminal fluid appeared to have normal values as reported by WHO. Non-significant (P>0.05) difference was observed for testicular size and diameter of seminiferous tubules between right and left testis. High and abnormal concentrations of serum FSH were registered for NOA patients with SCOS. However, non-significant (P>0.05) differences were reported for concentrations of serum reproductive hormones between smokers and non smokers. In conclusion, testicular biopsy is the useful and predictable diagnostic tool for NOA patients with SCOS. Further studies are needed to explain the etiology, management and prognosis of NOA patients with SCOS.
This is a randomized blind controlled prospective study included 123 males with primary infertility referred from private clinics from May 2004 to May 2005. ELISA was used to detect the antisperm antibodies in the seminal fluid of infertile males (60 patients with normal seminal fluid analysis and 63 patients with abnormal seminal fluid analysis). It was found that there was no significant difference in the incidence of antisperm antibodies between infertile males with normal seminal fluid analysis (10%) and those with abnormal seminal fluid analysis (%15.8) p>0.05, but most of infertile males with abnormal seminal fluid analysis (8 out of 10) their antibody titre was within high level (100-115) U/ml, while 5 out of 6 infertile patients with normal seminal fluid analysis, their antibody titre was with low level (60-75) years in both groups (infertile patients with normal seminal fluid analysis and abnormal seminal fluid analysis) and most affected infertile males were those with duration of infertility of 6-10 years. There was significant association (p<0.05) between smoking habit and abnormal seminal fluid analysis, while there was no significant difference between smoker and non smoker infertile males in the incidence of antisperm antibody (p>0.05).
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