Mortality among elderly married persons is associated with one's own and one's spouse's educational achievement. Research using partner's education as a proxy for one's own attainment may be omitting valuable information regarding these and other health risks.
The work productivity loss due to health problem estimated based on WPAI-GH was significantly higher in twenties than in forties (50% and 20%, respectively) (p=0.001). The result of a multivariate generalized-linear model after a model selection showed that the work productivity loss was significantly higher in females, twenties, and participants with a depressive tendency factor, extroversion, neuroticism, or openness personality, or high work load in November 2017. Conclusions: Youngest workers showed highest mental stress and largest productivity loss in the busiest season. The youngest generation who holds generally greater potential in the company is considered most exhausted in our study, which indicates a major issue for the working environment of Japanese companies.
combination was palbociclib with letrozole (21%). The most prescribed first-line CHT was paclitaxel (40%) and doxorubicin (40%). In second-line therapy, CHT increased to 60%. In those patients who started treatment before 2016, first line therapies were CDK4/6 inhibitors 4%, ET 62% and CHT 61% (39% of those who received two or more treatments). The most frequent first-line CHT was paclitaxel (33%) and the most frequent ET was anastrozole (46%). Sensitivity to hormonotherapy (defined as more than 36 months from the end of ET to beginning of first-line, 20% of all cases) and resistance to previous hormonotherapy (less than 24 months from beginning of ET to beginning of first-line or less than 6 months from beginning of hormone therapy first-line and second-line, 23.0% of cases) were identified as relevant prognostic factors for survival. Conclusions: Treatment patterns for advanced or metastatic breast cancer in Argentina are highly heterogeneous and have experienced substantial changes during the last years. The high CHT use indicates an unmet need for care.
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