The preparation and full characterization of a variety of mono-([L1-H]), di-([L2-H 2 ], [L2A-H2]), and tri-([L3-H 3 ]) 1,2,3-triazolium salts constructed form "clicked" hydroxybenzene derivatives are reported. Deprotonation with potassium hexamethyldisilazide, followed by in situ metalation, allowed for the synthesis of a series of mono-(L1•[M]), di-(L2•[M] 2 , L2•[M] 2 ), and trinuclear (L3•[M] 3 ) group 9−11 (M = [Rh(CO) 2 Cl], [Pd(allyl)Cl], and [AuCl]) triazol-5-ylidene metal complexes. In solution, all metal complexes feature symmetrical patterns displaying C 2 and C 3 fold axes when supported by di-and tritriazol-5-ylidene ligands. The vibration frequencies of Ln•[Rh(CO) 2 Cl] n (n = 1−3) complexes indicate that the electron-donor properties of the new ligands are comparable to those for previously reported MIC complexes and superior to classical NHCs. Prompting coordination of the vicinal phenoxy group to the metal centers proved unsuccessful after treatment of the Ln•[Rh(CO) 2 Cl] n and Ln•[Pd(allyl)Cl] n (n = 1−3) precursors with AgBF 4 ; the expected chelated cationic complexes were highly unstable, indicating a weak or no coordination availability through the oxygen atom. Crystal structures of the complexes L1•[AuI] and L2A•[Pd(allyl)I] 2 illustrated the metal center geometrical environment and confirmed the lack of coordination through the phenoxy moiety of the ligand. Preliminary catalytic trials established the enhanced performance of di-and trimetallic palladium complexes in cross-coupling reactions and the intramolecular cyclization of enynes catalyzed by gold complexes.

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Ten 1,4-disubstituted 1,2,3-triazoles were synthesized from one of 1-(azido-methyl)benzene, 1-(azidomethyl)-4-fluorobenzene, 1-(azidomethyl)-4-chlorobenzene, 1-(azidomethyl)-4-bromobenzene or 1-(azidomethyl)-4-iodobenzene, generated in situ from sodium azide and the corresponding benzyl halide, and dipropargyl uracil or dipropargyl thymine. Optimal experimental conditions were established for the conventional click chemistry. The corrosion inhibiting properties of some of these compounds, which were determined by means of an electrochemical technique, are also presented.

Following a copper catalyzed alkyne azide cycloaddition (CuAAC) and N-alkylation protocols, we report the preparation of a hybrid N-heterocyclic/mesoionic [NHC(H)-MIC(H)][2I] salt (1) in high yields. The treatment of salt 1 with CuO and KI yields a second hybrid NHC/MIC proligand featuring a tetraiodocuprate anion [NHC(H)-MIC(H)][CuI] (2). Through selective deprotonation and metalation, both salts 1 and 2 can generate either the chelate heterodicarbene complexes (3) with the rare [NHC·(M)·MIC][MX] general formula (M = Pd, Rh) or NHC-anchored/pendent triazolium species (4) [NHC·(M)-MIC(H)]. If the triazolium moiety of type 4 complexes is deprotonated with KHMDS in the presence of a second metal center, a series of heterobimetallic complexes of the type [NHC·(M)-MIC·(M')] (5) are achieved. Interestingly, the reaction of salt 2 with KHMDS yields the bimetallic copper heterodicarbene (6) which can be a useful transfer reagent for the preparation of type 3 complexes. A variety of synthetic routes for the preparation of complexes 3-5 and their full characterization in solution and in the solid state will be discussed.

Abstract:The catalytic ability of ZrO 2 /SO 4 2-to promote solventless three-component condensation reactions of a diversity of aromatic aldehydes, urea or thoiurea and ethyl acetoacetate was studied. Products resulting from Hantzsch and/or Biginelli multicomponent reactions are obtained in the presence of solid acid catalysts using the same reactants but different temperature conditions. The sulfated zirconia catalyst can be recovered and recycled in subsequent reactions with a gradual decrease of activity.

Reaction of triazolium precursors [MIC(CH ) - H ]I (n=1-3) with potassium hexamethyldisilazane (KHMDS) and AuCl(SMe ) generates the gold(I) complexes of the type MIC(CH ) ⋅AuI. Visible light exposure of the latter complexes promotes a spontaneous disproportionation process rendering gold(III) complexes of the type [{MIC(CH ) } ⋅AuI ] I . Both the Au and Au complex series were tested in the catalytic hydrohydrazination of terminal alkynes using hydrazine as nitrogen source.

Sulfated zirconia and SZ/MCM-41 were used as catalysts for the synthesis of β-aminoalcohols via epoxide aminolysis. Sulfated zirconia was prepared by sol-gel and SZ/MCM-41 was obtained by impregnation. Solid catalysts were characterized by XRD, SEM-EDS, UV-Vis, FT-IR pyridine desorption and Nitrogen physisorption. Both acid materials were useful as catalysts, even when they were recycled several times. The β-aminoalcohols were characterized by FT-IR, 1 H-and 13 C-NMR and GC-MS.

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