. (2015) Gold-catalyzed cycloisomerization and Diels-Alder reaction of 1,4,9-Dienyne Esters to 3 a,6-Methanoisoindole Esters with pro-inflammatory cytokine antagonist activity. Chemistry -A European Journal, 21 (25 Copies of full items can be used for personal research or study, educational, or not-for profit purposes without prior permission or charge. Provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way.
Publisher's statement:"This is the peer reviewed version of the following Susanti, Dewi, Liu, Li-Juan, Rao, Weidong, Lin, Sheng, Ma, Dik-Lung, Leung, Chung-Hang and Chan, Philip Wai Hong. (2015) Goldcatalyzed cycloisomerization and Diels-Alder reaction of 1,4,9-Dienyne Esters to 3 a,6-Methanoisoindole Esters with pro-inflammatory cytokine antagonist activity. Chemistry -A European Journal, 21 (25). pp. 9111-9118. which has been published in final form at http://dx.doi.org/10.1002/chem.201500795 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."
A note on versions:The version presented here may differ from the published version or, version of record, if you wish to cite this item you are advised to consult the publisher's version. Please see the 'permanent WRAP URL' above for details on accessing the published version and note that access may require a subscription. Abstract: A synthetic method to prepare 3a,6-methanoisoindole esters efficiently by gold(I)-catalyzed tandem 1,2-acyloxy migration/Nazarov cyclization followed by Diels-Alder reaction of 1,4,9-dienyne esters is described. We also report the ability of one example to inhibit binding of tumor necrosis factor- (TNF-) to the tumor necrosis factor receptor 1 (TNFR1) site and TNF--induced nuclear factor -light-chain-enhancer of activated B cells (NF-B) activation in cell at a half-maximal inhibitory concentration (IC50) value of 10 M. Along with this is a study showing the isoindolyl derivative to exhibit low toxicity toward human hepatocellular liver carcinoma (HepG2) cells and its possible mode of activity based on molecular modeling analysis.