42Hippocampal atrophy is a key pathologic and MRI feature of human Alzheimer's disease (AD).
43Hippocampal atrophy has not been documented via MRI in canine cognitive dysfunction (CCD), 44 which is considered the dog model of human AD. The purpose of this retrospective comparative 45 volumetric MRI study was to compare total hippocampal volumes between successfully aging 46 (control) dogs and dogs diagnosed with CCD. Mimics ® software was used to derive total 47 54 55 56 57 58 59 60 61 4 62 7 126 status (CCD vs control). Agreement between repeated measurements was examined using Limits 127 of Agreement analysis. 15 128
Results
129We included 16 dogs with CCD and 26 control dogs in the study. Dogs with CCD were older 130 than control dogs (median age 13 yrs vs 11.5 yrs; P=0.0002); however, we could detect no 131 negative correlation between advancing age and reduced hippocampal volume in either group 132 ( Figure 2). The CCD group comprised 2 Shih Tzus, 2 Springer spaniels and one each of 133
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