The SPA has high correlation with the Cobb angle. Including the AVR as an additional factor in multiple regression improves the prediction of the Cobb angle.

Both the intra- and interobserver assessment of the Cobb, VR, and SPA from the semi-automated measurements had clinically acceptable reliability ranges and may be considered for clinical implementation. Additional studies will be conducted to determine the accuracy and sensitivity to change of these scoliosis severity measurements.

Specifically, this paper reports on the effect that engineered peptides have on the formation of effective nucleation sites for self-assembly into nanofibers upon exposure to enzymes.