Chemotherapy against specific molecular targets is one of the most effective approaches used to treat
cancer patients. However, lack of selectivity and development of drug-resistance reduces the efficacy
of cancer chemotherapy. Therefore, development of effective and safe anticancer agents with high
potency and less toxicity is a major focus for researchers across the world. In the current article, the
utility of a reverse ligand similarity based approach to identify potential targets for a new series of
synthesized pyrazole carbothioamides that demonstrate the potent anticancer activities against MCF-
7 cells compared to other structurally related molecules and controls is discussed. Further, in silico
docking analysis provided insights into their sight of binding. Thus, these compounds show promise for
development as next generation anticancer drugs.
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