ChemInform Abstract The chloroarene complex (Ia) reacts with the carbonylferrate (II) to give (III), whereas analogous complexes (V) are prepared starting with (Ib). The use of (Ia) only leads to reductive dehalogenation of the arene complex. The classical η6-arene structure as opposed to the alternate possible η5-cyclohexadienide carbene valence form is assigned by spectroscopic data and confirmed by an X-ray analysis of (Vb) (Pca21, Z=4).
Formyl phosphate is the putative intermediate in the formylation of tetrahydrofolate (THF) catalyzed by No-formylTHF synthetase. In this study the non-enxymic reaction between formyl phosphate and THF was examined at 5°C. 'H-NMR, HPLC and kinetic analysis of the proton-catalyzed conversion of the product to N"si"-methenylTHF were used to identify the product. In contrast to the enzyme reaction, which produces NiO-formylTHF, Ns-formylTHF was the only formylated THF derivative formed. The reaction was conducted at pH values of 3, 5, and 7, with the highest yield being obtained at pH 5 (64-859g, based on THF). The enzyme, therefore, changes the ~~o~l~tivity of this reaction by increasing the reactivity of the IO-nitrogen and either decreasing the reactivity of the S-nitrogen or limiting its accessibility to formyl phosphate. Z-M~apt~th~ol, present in the reaction mixture to protect THF from 4, was also formylated by formyl phosphate, at the oxygen position. Formyl phosphate; Tetrahydrofolate; Formyltetrahydrofolate synthetase, N'e-
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