A natural prodrug is a chemical compound or substance obtained from plants, microorganism, animal and marine sources. Natural products are small molecule source for Food and Drug Administration approved drugs and major sources for drug discovery. Most of the drugs for different ailment diseases undergo first pass metabolism, resulting in drug inactivation and the generation of toxic metabolites in body. Enormous numbers of prodrugs naturally present in plants, microorganism, animal and marine sources and those prodrugs undergoes chemical reaction to form non-toxic compounds. This review summarizes the list of prodrugs naturally present in the natural product.

<p class="Abstract">The natural products are the chemical constituents that are generated from the living organism. The natural products are isolated from the plants, animals, and microorganisms which are used in drug design and drug discovery. Natural product is then modified by chemical synthesis as either total or semi-synthetic way. The natural products show various pharmacological activity which can be used for the treatment of a variety of diseases. Natural products could be regarded as a source of quantifiable and chemically pure known products and also natural products can be utilized as complex mixtures subjected to chemical variability. The present review article adds up the prodrugs from natural products as well as prodrugs developed from the natural products.</p>

A simple, accurate and highly sensitive spectrophotometric methods are proposed for the rapid and accurate determination of fluvoxamine maleate (FXA) using bromocressol green (BCG), methyl orange (MO) and bromothymol blue (BTB). The developed methods involve formation of stable yellow colored chloroform extractable ion-associate complexes of the amino derivative (basic nitrogen) of the FXA with three sulphonphthalein acid dyes, namely; BCG, MO and BTB, in potassium hydrogen phthalate buffer pH 3.3, 3.6 and 3.4 respectively. The ion-associates exhibit absorption maxima at 420, 420 and 410 nm for BCG, MO and BTB, respectively. FXA can be determined up to 2.0-16, 2.0-15 and 2.0-20 µgmL −1 for BCG, MO and BTB, respectively. The effect of optimum conditions via pH on the ion pair formation, reagent concentration, time and temperature, and solvent was studied. The composition of the ion pairs was found 1:1 by Job's method. The low relative standard deviation values indicate good precision and high recovery values. These methods have been successfully applied for the assay of FXA in pure form and in pharmaceutical formulations and the results are in good agreement with those obtained by the official method.

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