Available online xxx
Keywords:Triazine based dendrimer Ketoprofen Drug carrier Cytotoxicity Hemolysis a b s t r a c t Potential of nanoscale triazine based dendritic macromolecules G1, G2 and G3 as solubility enhancers of drug was investigated. Effect of pH, concentration and generation of synthesized dendritic macromolecules on solubility of ketoprofen was studied. G3 dendrimer was further exploited as carrier for sustained release. Ketoprofen was encapsulated by inclusion complex method and also characterized by Flourier Transform Infrared spectroscopy. Sustained release study of ketoprofen from ketoprofen loaded dendrimer was carried out and compared with free ketoprofen. Hemolytic potential and Cytotoxicity assay using A-549 lung cancer cell lines revealed that synthesized triazine based dendritic macromolecules having more potential that commercially available PAMAM dendrimer.
A series of eight novel heterocyclic based monoazo acid dyes were synthesized using various substituted imidazol-4-one as diazo component and coupled with various amino-napthol sulphonic acids. The resultant dyes were characterized using standard spectroscopic methods and then dyeing performance on wool fabric was assessed. Final results concluded that exhaustion (%E) of the dyes on wool fibers increased with decreasing pH of application and that fixation (%F ) of the dyes on wool fibers increased with increasing pH of application and the highest total fixation efficiency was achieved at pH 5. Wash and light fastness properties of prepared dyes showed encouraging results.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.