Recent studies have revealed that boron compounds can be effective in the treatment of obesity, which is known to be one of the most dangerous and complex health problems of this age. In this study, the therapeutic effect of boron molecules in the diet on obesity was investigated.
For this purpose, the effects of boron compounds on Total Antioxidant Status (TAS), Total Oxidant Status (TOS), High Density Lipoprotein (HDL) levels and paraoxanase (PON) activity were investigated in mice fed a high-fat diet.
The study material was 40 Sprague Dawley rats 4-5 months old with a mean live weight of 226.95 ± 5.75 g. Animals were divided into 4 groups as Group I (normal diet), Group II (High fat), Group III (High fat + Boric Acid) and Group IV (Boric Acid). Six weeks after the experiment, blood samples were taken from the animals and TAS, TOS, HDL levels and PON activity were measured from the samples. In addition, the live weight changes of the animals were recorded.
At the end of the study, we found that boric acid given in addition to drinking water did not significantly change TAS level and PON activity, but increased TOS and HDL levels. In addition, the weight average of the group treated with boric acid decreased.
As a result, boric acid did not have an effect on the antioxidant system, but it caused an increase in HDL level and a decrease in PON activity. In addition, boric acid can be effective in lowering body weight.
Diabetic nephropathy (DN) is one of the most common complications of diabetes mellitus (DM), as well as the most common health issue among End Stage Renal Diseases (ESRD). Recent studies have shown that this concern will likely to become a global phenomenon in the future. Early diagnosis of DN is vital for its treatment. MicroRNAs (miRNAs or miRs) are the most promising for new biomarker candidates proposed for DN. MiRNAs, known as non protein-coding short-chain RNA sequences, have a regulatory role in many cellular events. Advances in molecular genetics and successful genomic techniques allow miRNAs to be used in the diagnosis of several diseases. As the DN diagnostic markers used today are insufficient for some cases, identifying new diagnostic markers is the basis of recent studies. Successful use of miRNAs in the areas of cancer, immunity and diabetes indicates that the DN perspective should be based on miRNA. In this review, miRNAs and their role in DN will be reviewed.
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