The rational design of treatment is affected by two contradictory requirements: for diagnosis it is necessary to take into account all the factors of influence in the disease system, which requires long time and additional costs and also It is necessary to minimize the number of clinical determinations or the optimization of the medical act. A solution for eliminating this contradiction would be to reduce the number of parameters. The purpose of this study is to reduce the number of parameters by selecting factors with major influence in the course of the disease .This study began with the inventory of the diagnostic factors registered in the clinical observation sheet of 140 patients diagnosed with chronic myelogenous leukemia at the Hematology Department of Timisoara during January 2006 - January 2016. The statistical method of rank correlation used is a very effective solution of the problem, applicable in the medical field. The statistical hierarchy of the diagnostic criteria determines their ranks and allows focusing attention on the most important ones. The presented statistical study creates the theoretical and practical premises for the treatment to be differentiated, the disease to be recognized in a period as early as possible.
Chronic myeloid leukaemia is a malignant tumor of pluripotent haemopoetic stem cell, characterized by increase granulocytes with left shift and the presence of the Ph chromosome.Treatment of chronic phase is made with tyrosine kinase inhibitors administered orally and can have secondary effects: haematological and non-haematological. The purpose of this paper is to assess complications of tyrosine kinase inhibitor therapy in chronic phase of chronic myeloid leukemia and establishing correlations with the type of inhibitor used. The study was performed on a total of 140 patients diagnosed with chronic phase CML in the Hematology Department of the City Clinical Emergency Hospital Timisoara between January 2006 - January 2016. The lot proposed has been studied in terms of anthropometric parameters and also the haematological and biochemical. It showed complications after initiation of therapy with tyrosine kinase inhibitors and also the correlations statistically significant between complications and type of inhibitor used. The study reveals that regardless the type of inhibitor used both haematological complications arise and non haematological. The most common are: neutropenia, thrombocytopenia, anemia, fluid retention, muscle and joint pain. Less common are nausea, diarrhea, abdominal pain, increased liver enzymes. Despite complications of occurring, these modern therapies significantly improve both survival and quality of life of patients.
This paper presents studies made to establish the contribution of erosive phenomenon as a result of anodic dissolution during processing through complex electric � electrochemical erosion used in industry to cut very hard conductor materials. The authors propose a relative simple calculation method for the amount of anodic dissolution phenomenon into erosive balance of the process.
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