The emergence of multi‐drug resistant (MDR) bacteria poses a serious threat to human health. It has become imperative to develop efficient antimicrobial strategies. Here, a manganese‐doped dopamine‐derived hollow carbon sphere (MnOx/HNCS) is developed as a nanozyme and photothermal agent for the synergistic treatment of MDR bacterial infections. MnOx/HNCS possesses oxidase, superoxide dismutase, and peroxidase like activities and implements self‐cascading enzymatic catalysis to produce superoxide anion (O2•−), hydrogen peroxide (H2O2), and hydroxyl radicals (•OH). Importantly, near‐infrared light facilitates the electron transport of MnOx/HNCS, allowing it to exhibit stable photothermal effects and photo‐enhanced enzymatic activity. Thereby MnOx/HNCS displays a broad‐spectrum synergistic antibacterial efficiency in vitro against six MDR pathogens based on the above photo‐regulated properties. In vivo experiments further demonstrate the excellent antibacterial efficiency of MnOx/HNCS in the MDR bacteria‐infected wound model. Notably, MnOx/HNCS not only has excellent disinfection capacity, but also can accelerate wound healing by stimulating the deposition of the extracellular matrix and reepithelialization. This study proposes a promising antibiotics‐alternative broad‐spectrum antibacterial strategy and paves a new avenue for the establishment of multifunctional photo‐responsive synergistic therapeutic platform.
A 6ohp brushless doubly-fed machine (BDFM) pump drive, which is designed to replace an existing wound-rotor induction machine (WRIM) drive in a waste-water treatment plant, is discussed. Machine structural design as well as controller design are optimized according to the operational demands of the application. Thh paper focuses mainly on the controller design and implementation for the BDFM pump drive, in a limited-speed range of operation.The performance characteristics of the existing WRIM drive and the projected characteristics of the BDFM drive are presented. The microprocessor based drive controller is capable of performing start-up synchronization, speed control and near unity power factor operation. Additionally, the Controller generates a shut-down signal during fault conditions such as power failure and loss of synchronism. Experimental results obtained from a low-power laboratory prototype BDFM are presented to verify the 60hp design.
The aircraft anti-skid braking system (AABS) is an essential aero electromechanical system to ensure safe take-off, landing, and taxiing of aircraft. In addition to the strong nonlinearity, strong coupling, and time-varying parameters in aircraft dynamics, the faults of actuators, sensors, and other components can also seriously affect the safety and reliability of AABS. In this paper, a reconfiguration controller-based adaptive fuzzy active-disturbance rejection control (AFADRC) is proposed for AABS to meet increased performance demands in fault-perturbed conditions as well as those concerning reliability and safety requirements. The developed controller takes component faults, external disturbance, and measurement noise as the total perturbations, which are estimated by an adaptive extended state observer (AESO). The nonlinear state error feedback (NLSEF) combined with fuzzy logic can compensate for the adverse effects and ensure that the faulty AABS maintains acceptable performance. Numerical simulations are carried out in different runway environments. The results validate the robustness and reconfiguration control capability of the proposed method, which improves AABS safety as well as braking efficiency.
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