This study was carried out on a private vineyard, located in Sulaymaniyah governorate, Kurdistan Region-Iraq, during the growing season (2021) to investigate the effect of foliar applications of amino acids (Tecamin Max) (AA) at (0, 5, 10 mL/L), benzyl adenine (BA) at (0, 100, 200 mg/L), Nano-NPK fertilizer at (0, 2, 4 g/L) and their interactions on the productivity, physical and chemical fruit characteristics of grape cv. ‘Thompson Seedless’. The results confirmed that the highest concentrations of all applicants; AA, BA and Nano-NPK either solely or as a triple combination, recorded the higher values of the number of clusters per vine, cluster weight, total yield per vine, total sugars%, total soluble solids%, vitamin C, total carotene and total phenol contents in the berries. Triple interaction effects of AA + BA + Nano-NPK also resulted in many significant differences, in which 10 mL/L AA + 200 mg/L BA + 4 g/L Nano-NPK obtained the superior significant values of the number of clusters per vine (61.33), cluster weight (1.25 kg), total yield per vine (77.73 kg), total sugars (29.18%), and total soluble solids (29.9%). However, the highest mean value of vitamin C (3.63 mg/g f.w.) resulted from foliar application of 5 mL/L AA, both control and 100 mg/L BA and 2 g/L Nano-NPK, whereas the triple interactions of 10 mL/L AA+ 100 mg/L BA + 4 g/L Nano-NPK, and 5 mL/L AA + 0 mg/L BA + 4 g/L Nano-NPK gave the significant superior values of total carotene (3.01 mg/kg) and total phenol (1.46%) contents, respectively.