The ATTR Tyr69His mutation is associated with oculoleptomeningeal amyloidosis. Expression of the genotype is variable. This has implications for treatment of affected individuals and counseling of family members. Efficacy of liver transplantation in patients with oculoleptomeningeal amyloidosis remains unknown. The authors advocate the investigation of liver transplantation in patients with severe symptoms due to oculoleptomeningeal amyloidosis.
z-Axis ATCM is more effective than shields at reducing thyroid radiation dose during neck CT. Shields combined with ATCM slightly further reduces dose; however, this is associated with higher image noise.
Overall, the estimated dose from diagnostic CT examinations was similar to other previously published Canadian data from British Columbia. This dose varied slightly from some other published standards, including being higher than those found in a review conducted in the United Kingdom in 2003.
Reducing voltage and limiting z-axis is more effective than shields at reducing fetal dose. Shielding improves reduction with no significant difference between lead and bismuth-antimony shields when conservative scanning parameters are observed.
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