The China Meteorological Administration (CMA)'s tropical cyclone (TC) database includes not only the best-track dataset but also TC-induced wind and precipitation data. This article summarizes the characteristics and key technical details of the CMA TC database. In addition to the best-track data, other phenomena that occurred with the TCs are also recorded in the dataset, such as the subcenters, extratropical transitions, outer-range severe winds associated with TCs over the South China Sea, and coastal severe winds associated with TCs landfalling in China. These data provide additional information for researchers. The TC-induced wind and precipitation data, which map the distribution of severe wind and rainfall, are also helpful for investigating the impacts of TCs. The study also considers the changing reliability of the various data sources used since the database was created and the potential causes of temporal and spatial inhomogeneities within the datasets. Because of the greater number of observations available for analysis, the CMA TC database is likely to be more accurate and complete over the offshore and land areas of China than over the open ocean. Temporal inhomogeneities were induced primarily by changes to the nature and quality of the input data, such as the development of a weather observation network in China and the use of satellite image analysis to replace the original aircraft reconnaissance data. Furthermore, technical and factitious changes, such as to the wind-pressure relationship and the satellite-derived current intensity (CI) number-intensity conversion, also led to inhomogeneities within the datasets.

The sodium storage mechanism of hard carbon, optimization strategies of electrochemical performance, and the scientific challenges towards the commercialization of sodium-ion batteries were systematically summarized and analyzed.

Although borderline support for association between polymorphisms in TLR genes and AMD was reported for some cohorts, these initial observations of coding SNPs in TLR3, TLR4, and TLR7 were not replicated. TLR variants are unlikely to have a major impact on overall AMD risk, and the common variants studied were not associated with AMD.

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How the immune system recognizes endogenously arising tumors and elicits adaptive immune responses against nonmutated tumor-associated Ags is poorly understood. In search of intrinsic factors contributing to the immunogenicity of the tumor-associated Ag NY-ESO-1, we found that the NY-ESO-1 protein binds to the surface of immature dendritic cells (DC), macrophages, and monocytes, but not to that of B cells or T cells. Using immunoprecipitation coupled with tandem mass spectrometry, we isolated DC surface calreticulin as the receptor for NY-ESO-1. Calreticulin Abs blocked NY-ESO-1 binding on immature DC and its cross-presentation to CD8+ T cells in vitro. Calreticulin/NY-ESO-1 interactions provide a direct link between NY-ESO-1, the innate immune system, and, potentially, the adaptive immune response against NY-ESO-1.

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To explore the role of the testicular leptin and JAK-STAT[leptin (LEP)-JAK-STAT] pathway in testosterone biosynthesis during juvenile stages and exercise for weight loss, male C57BL/6J mice were randomly divided into normal-diet and high-fat diet groups. After 10 wk, mice in the high-fat diet-fed group were further divided randomly into obese control, obese moderate-volume exercise, and obese high-volume exercise groups. Mice in the obese moderate-volume exercise group were provided with 2 h/day, 6 days/wk swimming exercise for 8 wk, and mice in the obese high-volume exercise group underwent twice the amount of daily exercise intervention as the obese moderate-volume exercise group. The results showed that a high-fat diet causes obesity, leptin resistance, inhibition of the testicular LEP-JAK-STAT pathway, decreased mRNA and protein expression of steroidogenic factor-1, steroidogenic acute regulatory protein, and the -450 side-chain cleavage enzyme, a decrease in the serum testosterone-to-estradiol ratio, and declines in sperm quality parameters. Both moderate and high-volume exercise were able to reduce body fat and increase the mRNA and protein expression of LEP-JAK-STAT, but only moderate exercise significantly increased the mRNA and protein expression of steroidogenic factor-1, steroidogenic acute regulatory protein, and-450 side-chain cleavage enzyme and significantly reversed the serum testosterone-to-estradiol ratio and sperm quality parameters. These findings suggest that by impairing the testicular LEP-JAK-STAT pathway, early-stage obesity inhibits the biosynthesis of testosterone and sexual development and reduces male reproductive potential. Long-term moderate and high-volume exercise can effectively reduce body fat and improve obesity-induced abnormalities in testicular leptin signal transduction, whereas only moderate-volume exercise can reverse the negative impacts of obesity on male reproductive function.