Extradigital glomus tumours do not have specific clinical features such as pain, leading to frequent misdiagnosis. To prevent delay in diagnosis or misdiagnosis, it is important to increase awareness of these tumours.

Background: CD4＋ CD25 high＋ regulatory T cells (Tregs) are considered to be of vital importance for maintaining immunologic self-tolerance and preventing autoimmune diseases. These cells have been found to be deficient in skin lesions and in the peripheral blood of patients with psoriasis. Objective: To investigate the role of Tregs in the pathogenesis of psoriasis and to evaluate the changes in Tregs in relation to the severity and the clinical course of psoriasis. Methods: Immunohistochemistry (CD3, 4, 8, 79 and FOXP3) was performed in 22 psoriatic patients compared to 5 normal controls. Flow cytometry (CD3, 4, 8, 25 and FOXP3) was performed in 18 psoriatic patients and 8 normal volunteers and reverse transcriptase polymerase chain reaction (foxp3 mRNA) was performed in 8 psoriasis patients. Results: An increase in the FOXP3 ＋ cell fraction was detected in the lesional psoriatic skin irrespective of the severity of psoriasis as compared with the normal skin. However, a decrease in FOXP3 ＋ cells was observed in the samples obtained from psoriasis of 'acute course'. FOXP3 ＋ Treg populations in the blood of the 'acute course' psoriasis was not different compared to that of 'chronic course' psoriasis and normal controls. Conclusion: The deficiency of FOXP3 ＋ Tregs in the lesional psoriatic skin might be responsible for the exacerbation of psoriasis. (Ann Dermatol 22(4) 397∼403, 2010)

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Fig. 1. Gross appearance of the lesion. A 2-cm sized, welldemarcated, yellowish to brownish scaly plaque on the left lower abdomen was observed.

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Bednar tumor is a rare pigmented variation of dermatofibrosarcoma protuberans, present in 1 to 5% of all patients with dermatofibrosarcoma protuberans. No significant clinicopathologic differences exist between Bednar tumor and conventional dermatofibrosarcoma protuberans apart from the presence of scattered nonneoplastic pigmented dendritic cells in the former. Although most dermatofibrosarcoma protuberans occur in adults, they may be rarely present at birth. Fanconi anemia is a genetically heterogeneous chromosomal instability syndrome, characterized by multiple congenital anomalies, progressive bone marrow failure, and a predisposition to malignancy. We describe here a patient with Fanconi anemia who had a congenital Bednar tumor. To our knowledge, this is the first such patient described with both dermatofibrosarcoma protuberans and Fanconi anemia.

This paper proposes an approach to the classification of respiration states based on a neural network model by visualizing respiratory signals using a spectrogram. The analysis and processing of human biosignals are still considered some of the most crucial and fundamental research areas in both signal processing and medical applications. Recently, learning-based algorithms in signal and image processing for medical applications have shown significant improvement from both quantitative and qualitative perspectives. Human respiration is still considered an important factor for diagnosis, and it plays a key role in preventing fatal diseases in practice. This paper chiefly deals with a contactless-based approach for the acquisition of respiration data using an ultra-wideband (UWB) radar sensor because it is simple and easy for use in an experimental setup and shows high accuracy in distance estimation. This paper proposes the classification of respiratory states by using a feature visualization scheme, a spectrogram, and a neural network model. The proposed method shows competitive and promising results in the classification of respiratory states. The experimental results also show that the method provides better accuracy (precision: 0.86 and specificity: 0.90) than conventional methods that use expensive equipment for respiration measurement.