African Americans, testing for at least the 25 recommended mutations. Results: A total of 33 CF carriers were identified. The most common mutations detected were ⌬F508, G622D, R117H/7T, and G551D. The G622D allele frequency among African Americans was 0.18%. We did not detect any 3120ϩ1G3 A carriers, although 4 were expected (P Ͻ 0.05). Conclusions: When considering only the 25 recommended CF mutations, 1 in 75 African Americans screened in our laboratories were carriers (within the expected range, given a 69% mutation detection rate). The addition of 2 mutations, G622D and Q98R (incidentally
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