A previously uncharacterized glutathione (GSH) transferase which is not apparent in normal liver, accounts for at least 25% of the soluble GSH transferase content of primary hepatomas induced by feeding N,Ndimethykl-aminoazobenzene.This enzyme is readily isolated, has an isoelectric point of 6.8, is composed of two identical subunits of apparent A4, 26000 and has GSH transferase activity towards a number of substrates including benzo(a)pyrene-7,8-diol-9,10-oxide.It is unusual in that it has GSH peroxidase activity towards fatty acid hydroperoxides but not towards the model substrates, cumene hydroperoxide and t-butyl hydroperoxide. It has been shown by tryptic peptide analysis to be distinct from GSH transferases composed of subunits 1,2, 3,4 or 6 and has been designated GSH transferase 7-7.GSH transferase 7-7 GSH peroxidase Hepatoma Purification
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