Porphysomes (PS) were explored to incorporate different
types of
diethylenetriaminepentaacetic-acid-gadolinium-(III) (Gd-DTPA)-lipids
into their bilayer membrane to assess PS potential as an MRI contrast
agent. The Gd-dPS-BSA by integration of over 30% Gd-DTPA-bis(stearylamide)
(Gd-DTPA-BSA)-lipids in PS construction resulted in exceptional serum
stability and T1 and T2 relaxivity measurements
of 13 mM–1 s–1 and 19 mM–1 s–1, respectively. The Gd-dPS-BSA demonstrated
significantly enhanced retention in blood circulation with a half-life
of 13.6 h and high tumor accumulation up to 19.5%ID/g at 72 h post-injection
in select cancer mouse models. Additionally, Gd-dPS-BSA displayed
excellent MRI tumor enhancement over 24, 48, and 72 h with contrast
enhancements from the baseline of 35.8%, 38.2%, and 38.3%, respectively.
Results reported here highlight a high-density incorporation of Gd-DTPA-BSA-lipids
within PS, and other liposome formulations can enhance circulatory
longevity, independently of particles’ concentration, suggesting
effective MRI contrast agent potential for Gd-dPS-BSA and potential
utility of Gd-DTPA-BSA-lipids to enhance other liposomal-influenced
diagnostic and therapeutic functions.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.