The objective of this study was to investigate the quantitative characteristics of short tandem repeat (STR) variations deduced on the basis of the number of STRs that are beneficial for human survival. The longevity group included 60 nonagenarian subjects, and the control group included 250 reference adults (age, 20-50 years). Alleles of 15 Combined DNA Index System STR loci were determined using a commercial polymerase chain reaction kit. An STR with the highest frequency distribution in a population (control group) was considered as a conservative STR, and the number of core unit repeats of this STR allele was considered as the median repeat number in the STR locus (STRm). The absolute difference between the STRm and the number of core unit repeats of other STR alleles can be considered as the quantitative marker of variation for that particular STR allele (M value). The mean M values of CSF1TPO in the longevity group were significantly higher than those in the control group (P<0.05). These findings appear to suggest that at least one of the STR loci may be associated with longevity. The M value of STR may be a new and high-efficacy genetic marker.
Objective: We present a case of pheochromocytoma with fatal paroxysmal dyspnea hemoptysis and shock. A systematic review of literature on pheochromocytoma was performed to improve the understanding of the clinical manifestation, diagnosis and treatment of a typical pheochromocytoma. Methods:The clinical manifestation, diagnostic examination, operation mode and pathological characteristics of the typical pheochromocytoma, were analyzed and summarized. Simultaneously relevant literature was reviewed. Results:A 29-year-old male was diagnosed with pheochromocytoma with hemorrhagic cysts though without any typical clinical manifestation such as paroxysmal hypertension headache diaphoresis and palpitation. We treated this case as functional pheochromocytoma during the perioperative preparation although there were not enough evidence supporting that the tumor was pheochromocytoma. After sufficient preoperative preparation one of the adrenal grands was surgical resected and the diagnosis was confirmed on histopathology. Postoperation follow-up showed that the patient had a good prognosis after six months. Conclusion:The manifestations as we reported in this article fatal paroxysmal dyspnea hemoptysis and shock are quite rare as initial manifestations in pheochromocytoma. It showed that the initial manifestations of pheochromocytoma are complicated and deserve an appropriate examination and careful handling, which might reduce the misdiagnosis and surgical risk.
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