PBMC from ADF may be characterized by an impaired response induced by Aβ and by a reduced proliferative response responsible for the longer telomeres. TL might be a contributing factor in predicting the rate of AD progression.
Abstract. We investigated IL-10 and IL-6 production in amyloid- (A) stimulated peripheral blood mononuclear cells (PBMCs) in twenty Alzheimer's disease (AD) patients with slow progression, eleven with fast progression, and twenty age-matched controls. Promoter polymorphisms in IL-10 (position −592, −819, −1082), IL-6 (−174), transforming growth factor-1 (TGF-1) (−10, −25), interferon-␥ (IFN-␥) (−874), and tumor necrosis factor-␣ (TNF-␣) (−308) genes were analyzed. IL-10 production after A stimulation was high in PBMCs from slow decliners and almost completely abrogated in fast decliners. Association between AA IFN-␥ low-producing genotype and fast progression was demonstrated. Investigations in a larger sample will clarify these findings.
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