Hyperglycemia is a condition of increased blood glucose levels caused by insufficient insulin enzymes produced to control blood sugar levels in the body. This study aimed to determine the activity of ethanol-water, nhexane, and ethyl acetate extracts of Dioscorea alata L. in reducing blood glucose levels in hyperglycemia modeled mice that were given intraperitoneal alloxan induction. 25 white rats were divided into 5 groups of test animals. Each group consists of 5 mice. The first group was given 0.5% sodium carboxymethylcellulose solution as a placebo, the second group was given 0.65 mg/kg BW glibenclamide as a positive comparison group, the third group was given the suspension of ethanol-water extract, the fourth group was given n-hexane extract, and the fifth group was given ethyl acetate extract at a dose of 140 mg/kg BW. The test preparation was orally given within 14 days of testing. The test was measured as the initial blood glucose levels of mice after alloxan induction and after giving the test preparation suspension. The results of the qualitative analysis illustrate that the water-ethanol extract can reduce blood glucose levels by 31.39%, n-hexane extract by 51.11%, and ethyl acetate extract by 50.77%. The results of quantitative analysis using One Way ANOVA method showed that the water-ethanol, n-hexane, and ethyl acetate extracts significantly decreased the blood glucose levels of mice. The best antidiabetic activity was ethyl acetate extract with a decrease in rat blood glucose levels by 169 mg/kg BW.
Diabetes Melitus (DM) merupakan penyakit gangguan metabolik menahun akibat pankreas tidak memproduksi cukup insulin sehingga terjadi peningkatan konsentrasi glukosa di dalam darah. Penelitian ini bertujuan untuk mengetahui efek antidiabetes dan mengetahui fraksi mana yang memberikan hasil optimal terhadap penurunan kadar glukosa darah dari fraksi n-Heksan, Etil Asetat, dan Air Uwi Banggai (Dioscorea alata L.) pada mencit jantan (Mus musculus) yang diinduksi aloksan. Penelitian ini menggunakan 25 ekor mencit yang dibagi menjadi lima kelompok yang masing-masing kelompok terdiri dari 5 ekor mencit. Kelompok pertama kontrol negatif (Na-CMC 0,5%), kelompok kedua kontrol positif (Glibenklamid 0,65 mg/kgBB), kelompok ketiga fraksi n-Heksan, kelompok keempat fraksi etil asetat, dan kelompok kelima fraksi Air dengan dosis yang sama untuk ketiga jenis fraksi yaitu 140 mg/kgBB. Pemberian sediaan uji dilakukan secara oral selama 14 hari. Penelitian telah dilakukan terhadap uji antidiabetes fraksi dari ekstrak etanol Uwi Banggai Ungu (Dioscorea alata L.) pada mencit jantan yang diinduksi aloksan dengan dosis 140 mg/kgBB secara intraperitonial. Parameter yang diukur adalah kadar gula darah mencit. Hasil penelitian menunjukkan bahwa fraksi etil asetat memberikan aktivitas penurunan kadar gula darah sebesar 169 mg/dL. Persentase efek penurunan kadar gula darah fraksi n-heksan sebesar 51,11%, fraksi etil asetat 50,77%, dan fraksi air 31,39%.
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