The relevance of Africentric values and beliefs has been articulated by a number of African American scholars. Moreover, Africentric frameworks have been used in the design and implementation of substance abuse prevention programs. The purpose of this study was to investigate the role of Africentric values along with self-esteem and Black identity on drug attitudes amongfifth graders. Measures of Africentric values, self-esteem, and Black identity were obtained from 54 African Americanfifth graders. A regression analysis indicated that Africentric values significantly explained drug attitudes. Self-esteem andiBlack identity were not significant contributors to explaining drug attitudes. Self-esteem and Black identity were significantly related to each other; self-esteem was negatively correlated with Africentric values. The findings of the study are discussed, including the implications for the inclusion of Africentric values when looking at drug attitudes and behaviors.