The biofunctionality of native and nanostructured starch obtained from blue corn was evaluated on prediabetic Wistar rats. The surface of both types of starch was analyzed by atomic force microscopy (AFM). Total polyphenols content, antioxidant activity and digestibility were also evaluated. Prediabetes was induced by feeding a diet high in fat, carbohydrates and the administration of streptozotocin. Experimental design included a control group, prediabetic group and two prediabetic groups, one supplemented with native starch and the other with nanostructured starch. AFM analysis showed nano-cavities <5 nm in nanostructured starch. Nanostructured starch also had a higher content of total polyphenols, higher antioxidant activity and higher percentage of slow digestibility starch compared to native starch. Glucose, triglycerides 34 and insulin in the plasma increased significantly in the prediabetic group. Nanostructured starch administration decreased the levels of glucose and insulin in the plasma and therefore has potential as functional ingredient.
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