Objective: A routine dissection of the cadaver of a 67-year-old man revealed a very rare morphological variant of the great cardiac vein (GCV). Presentation: The vein originated in the upper third of the anterior interventricular sulcus, crossed the anterior interventricular artery superficially, ran beneath the circumflex artery, crossed the transverse pericardial sinus, and drained directly into the superior vena cava. Conclusion: This variant of the GCV is interesting due to its rarity. It is important to know about it for procedures that require venous access such as coronary surgery requiring retrograde cardioplegia, surgical ablation of aberrant conducting pathways, pacemaker insertion, and valve surgery.

The study is an immunohistochemical evaluation of the microvascularisation of the human kidney. The study group consisted of 45 post‐autopsy human renal pieces from adults with no renal affections. The common usual histopathological processing and the HE, PAS and Gomori trichrome staining allowed the morphological evaluation of the preparations. Immunohistochemical staining with anti‐CD31 and anti‐CD34 monoclonal antibodies were performed for all the cases included in the study. Vasa vasorum (VV) were revealed in interlobe, arcuate and interlobular vessels, and perivascular capillary luxuriant plexuses were identified mainly at the arterial adventitial level (arterial vasorum plexuses). Larger veins have internal VV that originate from the venous luminal area, have a centrifugal course, are directed to the periadventitial tissues and are apparently connected to microvascular structures derived from the peritubular capillary network. External microvascular elements and the aspect of the capillaries suggest vasorum neovascularisation at vein level. The presence of muscle arterioles and endothelial tubes disposed symmetrically to venous lumina can give birth to extrinsic vascular sphincters, which can slow down the venous flow and reduce protection of the renal parenchyma against ischemia. The degree of VV in the media and intima of an artery correlates with the risk of ischemic lesion.

This article has been peer reviewed and published immediately upon acceptance.It is an open access article, which means that it can be downloaded, printed, and distributed freely, provided the work is properly cited. Articles in "Folia Morphologica" are listed in PubMed.

Patients diagnosed with low-grade squamous intraepithelial lesion ((L-SIL) or atypical squamous cells of undetermined significance (ASC-US) are subjected to additional investigations, such as colposcopy and biopsy, to rule out cervical intraepithelial neoplasia 2+ (CIN 2+). Especially in young patients, lesions tend to regress spontaneously, and many human papilloma virus (HPV) infections are transient. Dual-staining p16/Ki-67 has been proposed for the triage of patients with ASC-US or L-SIL, but no prospective study addressing only this subgroup of patients has been conducted so far. We performed a prospective study including all eligible patients referred for a loop electrosurgical excision procedure (LEEP) in the Department of Obstetrics and Gynecology of Timișoara University City Hospital. HPV genotyping and dual-staining for p16/Ki-67 were performed prior to LEEP, at 6 and 12 months after LEEP. A total of 60 patients were included in the study and completed the follow-up evaluation. We analyzed the sensitivity and specificity for biopsy-confirmed CIN2+ using the 95% confidence interval (CI) of high-risk human papilloma virus (HR-HPV), dual-staining p16/Ki-67, colposcopy, and combinations of the tests on all patients and separately for the ASC-US and L-SIL groups. Dual-staining p16/Ki-67 alone or in combination with HR-HPV and/or colposcopy showed a higher specificity that HR-HPV and/or colposcopy for the diagnosis of biopsy confirmed CIN2+ in patients under 30 years. Colposcopy + p16/Ki-67 and HR-HPV + colposcopy + p16/Ki-67 showed the highest specificity in our study.

During the routine dissection of a 67‐year‐old male within our university's Department of Anatomy, we identified multiple renal vascular and ductal anomalies.The left kidney was irrigated by three arteries, two with a hilar penetration and one inferior polar artery. All three of these arteries originated from the aorta – two on the anterior side, at the L1 and L3 levels respectively, and the inferior one on the posterior face of the aorta, at the same level as the median sacral artery (L5). All three arteries had accompanying veins. The upper‐most artery was accompanied by the main renal vein, the middle artery – by one of the renal vein's tributaries, and the inferior one by two veins, which joined and opened into the left common iliac vein.The right kidney had two renal arteries, both of aortic origin – the superior one at the L1 level, 0.5cm below the superior mesenteric artery, and the inferior one on the anterior side of the aorta, at the L5 level and at the point where the aorta split into the two common iliac arteries. The superior artery entered the kidney through the sinus and was accompanied by the right renal artery. The inferior artery entered the kidney through the inferior pole, accompanied by a renal vein that drained into the left common iliac vein together with the left inferior polar renal vein.In both kidneys, the renal pelvis was anterior of the vessels, with the ureters having a descending path on the anterior side of the kidneys.Familiarity with such variations in renal vascular and ductal elements is critical for surgical interventions such as for total or partial nephrectomies, aortic aneurysms or renal artery reconstruction for stenosis.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.