Neat grinding and solvent-drop grinding methods are found to be effective screening tools for indicating the potential for crystalline salt formation involving a given acid-base pair, as demonstrated with two model pharmaceuticals.
Either of two different isomeric
products can be selectively obtained
by photochemical [2+2] cycloaddition of 1,4-bis[2-(4-pyridyl)ethenyl]-benzene
within a porous coordination polymer (PCP). The cycloaddition product
obtained depends on the temperature at which irradiation occurs. A
rare temperature-induced phase transition alters the conformation
of the photoactive ligand in the PCP, and thereby the positions at
which cycloaddition occurs. We show that the multistimulus responsive
nature of this particular PCP is due to the flexibility of the ligands
employed.
The sterically protected dithiadiazolyl radical (F3C)3C6H2CNSSN. (1) crystallises in two polymorphs: 1alpha, comprised of monomeric units and 1beta, containing a mixture of both pi*-pi* dimers and S = (1/2) monomers; whilst both polymorphs exhibit similar structure-directing motifs, the variation in packing leads to different magnetic behaviour.
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