Fused phenylcycloalkyl derivatives Q 1040Combination of RCM and the Pauson-Khand Reaction: One-Step Synthesis of Tricyclic Structures. -A tandem ring closing metathesis -Pauson-Khand reaction of dienynes causes formation of [6,5,5] or [7,5,5] tricyclic ring systems. In the first step, the C-C triple bond is masked as hexacarbonyldicobalt complex to avoid enyne metathesis. In the second step, the cobalt complex serves as carbonyl source for the Pauson-Khand reaction. The success of the tandem reaction depends significantly on the substrate structure, namely the presence of heteroatoms and ring size of the system formed. The [6,5,5] tricyclic systems are obtained as single diastereomers [cf. (XVIa), (II)]. -(ROSILLO, M.; ARNAIZ, E.; ABDI, D.; BLANCO-URGOITI, J.; DOMINGUEZ, G.; PEREZ-CASTELLS*, J.; Eur.
Cyclopentane derivatives Q 0030An Efficient Catalytic Protocol for the Pauson-Khand Reaction. -The new procedure is based on molecular sieves and tBuOH. This mixture, with the appearance of a paste, is able to adsorb CO and thus makes it possible to effect the reaction in the absence of a CO atmosphere. The protocol is applied to various substrates and compared to previous conditions, showing similar results. -(BLANCO-URGOITI, J.; ABDI, D.; DOMINGUEZ, G.; PEREZ-CASTELLS*, J.; Tetrahedron 64 (2008) 1, 67-74; Dep. Quim., Fac. Farm., Univ. San Pablo-CEU, E-28668 Madrid, Spain; Eng.) -Bartels 17-054
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