Chelation-assisted Rh-catalyzed C2-selective oxidative C-H/C-H cross-coupling of indoles/pyrroles with heteroarenesThe chelation-assisted strategy has been endowed with some novel functions in the Rh(III)-catalyzed dehydrogenative coupling of indoles/pyrroles with heteroarenes. Besides achieving the C2/C3 regioselectivity switching of indoles/pyrroles, the strategy can close the homo-coupling pathway of coupling partner, and dramatically extend substrate scope, showing a further benefi cial aspect of the Rh(III) catalysis.
In this work, an aerobic copper-catalyzed intramolecular C(sp(3))-H amidation has been disclosed, which presents a rare example of copper-catalyzed functionalization of an unactivated C(sp(3))-H bond with O2 as the sole oxidant. In addition, a new protocol for the preparation of a removable 5-methoxyquinolyl moiety has been documented.
An inexpensive Co(iii)-catalyzed direct oxidative C–H/C–H cross-coupling reaction of acrylamides with triisopropylsilylacetylene to synthsize (Z)-1,3-enynes is presented.
A rhodium(III)-catalyzed dehydrogenative cross-coupling reaction has been developed for the synthesis of bi(hetero)aryl structures by using oxime ethers as the directing group. This protocol features a relatively broad substrate scope and a good tolerance of functional groups.
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