The direct electrophilic α-cyanation of β-keto esters and amides has been developed using a hypervalent iodine benziodoxole-derived cyano reagent. The procedure is accomplished within 10 min and without the use of any catalyst in DMF, at room temperature. Thus, the highly functionalized quaternary carbon-centered nitriles were produced in high to excellent yields.
A radical trifluoromethylarylation of N-arylacrylamides with in situ generated [AgCF3] species from Me3SiCF3 and AgF in DMF is established through a tandem radical addition and C?H activation pathway. It provided a concise method to prepare 21 examples of CF3-containing oxindoles within four hours.
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