<p><strong> </strong></p><p class="abstract"><strong>Background: </strong>Mucormycosis is a life-threatening fungal infection that occurs in immunocompromised patients. There has been increasing number of mucormycosis cases during COVID-19 pandemic and also as post COVID-19 sequelae. Our study aimed at scrutinizing a possible coinfection of invasive mycoses and COVID-19 and also its management</p><p class="abstract"><strong>Methods: </strong>We did a retrospective case study of 25 patients presenting as invasive fungal infection from March -December 2020. Majority of patients were immunocompromised, since they presented during the pandemic, all patients were subjected to rapid antigen and RT -PCR testing for COVID-19.</p><p class="abstract"><strong>Results: </strong>11 patients tested COVID-19 positive out of 25. Diagnosis of mucormycosis was based on clinical features, culture, and histopathology from sinus biopsy. COVID-19 positive patients were managed in the high dependency units and COVID-19 wards. Severe COVID-19 positive patients were empirically started on IV Amphotericin based on clinical suspicion of mucormycosis and were taken up for debridement once stable. Negative patients underwent surgical debridement and were started on IV Amphotericin postoperatively.</p><p class="abstract"><strong>Conclusions: </strong>There have been lot of case reports from India showing COVID-19 recovered patients presenting with invasive fungal infections, this could be because of their immunocompromised status and long-term corticosteroid use. In our case series we had three patients with post COVID-19 mucormycosis. There was a surge in COVID-19 positive mucor cases during August and September which also coincided with the maximum peak of cases in India, thereafter, there has been a declining trend. There have been significant challenges in treatment modality and outcome due to the pandemic.</p>
Formability of AA5182-O aluminum alloy sheets in the warm working temperature range has been studied. Forming limit strains of sheets of two different thicknesses have been determined experimentally in different modes of deformation (biaxial tension, plane strain and tension-compression) by varying temperature and punch speed. A correlation has been established for plane strain intercept of the forming limit diagram (FLD 0) with temperature, punch speed and thickness from the experimental results. This correlation has been used to plot the forming limit diagrams for failure prediction in the finite element analysis of warm deep drawing of cylindrical cups. The effect of strain and strain rate on material flow behavior has been incorporated using a strain rate-sensitive power hardening law in which the strain hardening exponent and strain rate sensitivity index have been experimentally determined. The predictions from simulations have been validated by warm deep drawing experiments. Large improvement in accuracy of failure prediction has been observed using the FLDs plotted based on the developed correlation when compared to the existing method of calculating FLD 0 using only strain hardening coefficient and thickness. The results clearly indicate the importance of incorporating temperature and punch speed in failure prediction of Al alloys using FLDs in the warm working temperature range.
<p>Ewing's sarcoma (ES) first described by James Ewing in 1921, is a primary neoplasm of the skeletal system. Extraskeletal Ewing’s sarcoma (EES) is a rare, rapidly growing, round cell malignant tumour that can develop in the soft tissue at any location. Extraskeletal Ewings sarcoma of the head and neck is uncommon. Nearly 80% of patients are younger than 20 years with peak incidence in the second decade. Ewings sarcoma rarely affects the sinonasal tract. Diagnosis is after histopathological examination immunohistochemical studies and cytogenetic studies. Treatment will include a multidisciplinary approach with surgery as the first line followed by chemotherapy and radiotherapy. Ewings sarcoma in the head and neck region do not metastazise early hence carries a better prognosis. Evaluation of lesion using imaging, biopsy followed by histopathology and immunohistochemistry and cytogenetic analysis are necessary for early diagnosis and treatment. We present a case of an 18-year-old male patient with left sided epistaxis and left sided nasal obstruction, on examination a mass was seen the nasal cavity, endoscopic excision and biopsy of the mass was suggestive of an Ewings sarcoma. He received post-operative chemotherapy and radiotherapy. 2 years on regular follow up patient is fine without signs of metastasis or recurrence. We are presenting this case due to the rarity of its presentation in the sinonasal tract.</p>
Significant improvement in formability of aluminum alloys can be obtained when these materials are formed in the warm working temperature range (below recrystallization temperature). In the present work, an experimental set up is designed and developed to determine formability of Al-Mg-Si alloy (AA 6061) sheets of different thickness in the temperature range of 200-300 C. It consists of lower and upper dies with casing heaters, a hemispherical bottom punch with heating element, controls for punch displacement and speed of the 60-ton double action hydraulic press used in the experiments. An attempt has been made to experimentally determine the influence of punch speed, temperature, and sheet thickness on the limiting dome height and forming limit diagram in the warm working temperature range. The effect of temperature and strain rate on tensile properties of the alloy has also been studied. The plane strain intercept values of forming limit diagram (FLD 0 which is the major strain value at zero minor strain), determined experimentally at different conditions and thicknesses, have been used to develop a correlation for FLD 0 with temperature, punch speed and thickness. The FLD 0 values obtained from the developed correlation agreed well with the experimental values with the difference less than 10% in most cases. The confirmatory experiments at an intermediate punch speed showed an error of just 8%. The effect of temperature and punch speed on strain distribution in the forming limit diagram samples and the load-displacement curves has also been analyzed.
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