Introduction: Diabetes mellitus (DM) is a predominant source of morbidity in India. The incidence of depression is found to be increased among type 2 DM patients that makes the glycemic control as an exhaustive task and also leads to increasing the risk of diabetes induced complications. Aim: The present study aimed at studying the effect of three yoga on depression and glycemic control in type 2 DM patients. Methods: Nadi Shuddhi Pranayama, Kati Chakrasana and Vakrasana were taught to the recruited participants and clinical characteristic were measured at baseline, visit 1 and visit 2. Results: The mean FBS, PPBS and RBS values of the participants during the two visits were found to be decreased from 131.33±12.89 to 122.33 ± 10.63 (p <0.0001), 183.3 ±28.02 to 167.11 ± 13.95 (p=0.0052) and 181.81 ± 20.8 to 169.22± 21.79 (p=0.0050) respectively. The HAM D score of SIGH D tool from baseline to visit 2 was found to be reduced from 9 to 3.44 (p<0.0001). Conclusion: The study showed the evidence of the effectiveness of yoga in the management of depression and glycemic control in type 2 diabetes mellitus patients This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.