Background: Transfusion transmitted infections (TTIs) are a major problem associated with blood transfusion practices. Aims & Objectives: The present study was conducted to estimate the prevalence of transfusion transmitted infections among blood donors in one of the blood bank in Bareilly city. Materials and Methods: In this retrospective study, we reviewed healthy blood donors, over a period of one year (Jan 2013-Dec 2013), from the records of the blood bank of Indian Medical Association (IMA) at Bareilly for HBsAg, Hepatitis C Virus (HCV), HIV and Syphilis, by using the appropriate enzyme-linked immunosorbent assay. HIV infection was confirmed using a standard immunoblotting technique. Hepatitis B Virus (HBV) was tested for surface antigen (HBsAg) and HCV by the immune chromatographic method. The Venereal Disease Reference Laboratory (VDRL) test was used for estimation of syphilis infection. The study was designed for a duration of four months from April 2012 to July 2012. Medical reports of the donors were accessed from the hospital records and analyzed. Results: A total of 28,395 blood donors were screened. 60.43% were replacement donors, and 39.57% were voluntary donors. 95.21% were males. The overall seroprevalence of HBV, HCV, HIV and Syphilis were 1.93%, 1.02%, 0.27% and 0.16% respectively. Conclusion: Strict selection of blood donors with emphasis on getting voluntary donors, and comprehensive screening of donors for TTIs using standard methods are highly recommended to ensure the safety of blood for recipient.
Background: Cervical cancer is the most common cancer among females in India. It is also one of the major causes of deaths among them. Papanicolaou (Pap) cytological test helps in detecting the early epithelial abnormalities in cervical cells. The morbidity and mortality due to cervical cancer has come down in countries with well-established screening programmes at national level. This study was conducted to emphasize the value of cervical screening as a tool for early detection of non-neoplastic and neoplastic lesions of cervix. Slide positivity rate was computed and clinico-pathological correlation was done. Methods: This cross-sectional study was conducted from January 2012 to December 2014 (3 years), on 2202 women aged between 20-70 years coming for a Pap smear examination in a tertiary care hospital in Bareilly, India. After staining with conventional Papanicolaou technique, all cases were classified as per Bethesda nomenclature (2001). Results: Out of 2202 cases, 85.16% slides were found to be negative for intraepithelial abnormalities and 14.84% slides were labelled as positive for epithelial lesions. 97.67% of high grade lesions were found in women more than 40 years. Smears with epithelial cell abnormality were found more common in older age groups whereas smears negative for epithelial cell abnormality were found more common in young age groups. Conclusion: Pap test is a cost effective cancer screening and is a simple method to detect various lesions of cervix, non-neoplastic as well as neoplastic. High risk screening programmes should be directed to all women >40 years. Pap test is especially useful to diagnose precancerous lesions of cervix, thereby early detection of these lesions & subsequent proper treatment can be helpful in prevention of cervical cancer.
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